INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
A substantial proportion of the population of females in India falls in the perimenopausal and postmenopausal age
groups. One of the complications associated with older age in women is the weakening of bones and the fall in bone mineral density
(BMD). This has a severe debilitating consequence in a woman’s life and leads to reduced quality of life along with a greater
incidence of fractures. If the fracture involves the hip or the vertebrae, it can cause immobility and be devastating. Postmenopausal
osteoporosis is linked with the deficiency of estrogen that occurs with the cessation of the function of the ovaries as age progresses.
The function of estrogen in the bone remodeling process is very well understood after years of research; estrogen plays a part in
both the formation of bone as well as the prevention of the resorption of bone. A diagnosis can be made by dual-energy X-ray
absorptiometry (DEXA). It is the gold standard and can spot low bone density at particular sites. The treatment options are selected
according to the severity and rate of progression and factors pertaining to each patient. All postmenopausal women should be made
aware of this disorder, and they should be encouraged to cultivate a healthy lifestyle through the implementation of a proper diet
and inculcation of a regular exercise routine. Smoking and drinking alcohol should be limited, and calcium and vitamin D
supplementation should be started in all women of the postmenopausal age group with or without osteoporosis. In patients who
have been diagnosed with the disorder, pharmacological intervention is done. Drugs should be selected based on their side effects
and contradictions. Follow-up is essential, and patient compliance should be carefully monitored. This article attempts to review
the existing literature on this very prevalent disorder to spread awareness about it so that all postmenopausal women can take the
necessary steps to prevent the weakening of their bones, and deal with its progression.
Keywords:
fractures, estrogen, bone remodeling process, dual-energy x-ray absorptiometry, bone formation, postmenopausal osteoporosis, bone mineral density.
Cite Article:
"Pharmacodynamic and efficacy of the denosumab patient compared to the reference product (Prolia®) in postmenopausal osteoporosis women.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 5, page no.c726-c734, May 2023, Available :http://www.ijnrd.org/papers/IJNRD2305293.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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