A review on gastro-retentive mucoadhesive microspheres

A review on gastro-retentive mucoadhesive microspheres

Registration ID: IJNRD_193864

Published ID: IJNRD2305189

DOI: Click Here to Get

Rajesh h j , Dr. Parthiban S

gastroretentive drug delivery, physiology of stomach, mucoadhesive microsphere preparation, evaluation, current research outcome.

Drugs that are easily absorbed from the gastrointestinal tract (GIT) and have a short half-life are eliminated quickly from the blood circulation and require frequent dosing. To avoid this, and increase the gastric residence time developed GRDDS. The gastroretentive drug delivery system is a novel drug delivery system to prolong gastric retention time thereby targeting the drug to the desired site i.e. to the upper gastrointestinal tract for local or systemic action improving the bioavailability of the drugs. Mucoadhesion is the process whereby synthetic and natural polymers adhere to mucosal surfaces in the body. If these materials are then incorporated into pharmaceutical formulations, drug absorption by mucosal cells may be enhanced or the drug will be released at the site for an extended period. mucoadhesive drug delivery systems generally are the family of hydrogels, such as natural gums, polyacrylates, and cellulose ethers. Microspheres, in general, have the potential to be used for targeted and controlled-release drug delivery. Mucoadhesive microspheres are an ideal targeting system with high safety profile and have been developed for oral, buccal, nasal, ocular, rectal, and vaginal for either systemic or local effects.

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"A review on gastro-retentive mucoadhesive microspheres", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 5, page no.b680-b690, May-2023, Available :https://ijnrd.org/papers/IJNRD2305189.pdf

Volume 8 Issue 5, May-2023

Pages : b680-b690

Paper Reg. ID: IJNRD_193864

Published Paper Id: IJNRD2305189

Downloads: 000121164

Research Area: Pharmacy

Country: Mandya , Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2305189.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2305189

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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