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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | ANTICANCER ACTIVITY OF CASSIA SENNA (L) AGAINST PROSTATE CARCINOGENESIS |
| Authors Name: | MR. AYUSH B.CHAVHAN , DR. RANAJIT D. TIJARE , MR. OMKAR S. DAWARE |
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| Author Reg. ID: |
IJNRD_192420
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| Published Paper Id: | IJNRD2304556 |
| Published In: | Volume 8 Issue 4, April-2023 |
| DOI: | |
| Abstract: | In Western nations, prostate cancer (PC) is the most prevalent male non-cutaneous tumour. Since testosterone's metabolic conversion to 5 dihydrotestosterone (DHT) through 5 reductase, as well as genetic predisposition and promotion pathways, play a role in the development of prostate cancer. In the current investigation, testosterone and N-Methyl N-Nitroso Urea (MNU) were used as test subjects for the Cassia senna ethanolic extract's (4-month, 150 mg/kg body weight) anticancer efficacy. After treatment with an ethanolic extract of C. senna, biochemical measurements such as those of prostate acid phosphatase, lipid peroxidation, enzymic antioxidants, and non-enzymatic antioxidants activity were recovered. Histopathological analysis shown important alterations, such as hyperplastic prostatic acini and malignant proliferation of ductal epithelial cells in the prostate and seminal vesicle of carcinogen-induced rats. After receiving the C. senna extract, the prostate showed typical, flow-dilated ducts, acini with regular epithelial lining, and seminal vesicles showed partially hyperplastic and partially flattened epithelium. Based on these data, it is concluded that the ethanolic extract of C. senna effectively inhibits the growth of prostate tumours in an in vivo model that induces prostate carcinogenesis using testosterone and N-methyl N-nitrosourea. |
| Keywords: | MNU, Testosterone, Cassia senna, prostate carcinogenesis, antioxidants. |
| Cite Article: | "ANTICANCER ACTIVITY OF CASSIA SENNA (L) AGAINST PROSTATE CARCINOGENESIS ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 4, page no.f482-f492, April-2023, Available :http://www.ijnrd.org/papers/IJNRD2304556.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2304556 Registration ID: 192420 Published In: Volume 8 Issue 4, April-2023 DOI (Digital Object Identifier): Page No: f482-f492 Country: YAVATMAL, MAHARASHTRA, INDIA Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2304556 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2304556 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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