Paper Title
The Vesicular Transfersome: An Permeation Enhancer Carrier of Low Permeability Drug
Article Identifiers
: Authors
Keywords
Transfersomes, Deformable and Ultra Vesicles, Transdermal Route, Edge Activators, Phosphatidylcholine, Stratum Corneum.
Abstract
The aim of the research was to develop the Transfersomes, a novel vesicular carrier for the better activities of anti-inflammatory by reducing the gastro intestinal toxicity which associated with oral administration. Drug including Transfersomes prepared by Thin Film Hydration Techniques using surfactants is an edge activator, phospholipids and drug use in different ratios. The prepared Transfersomes were evaluated for the particle size, entrapment efficiency, zeta potential, in vitro drug release, and transmission electron microscopy. The drug and Excipients compatibility were done by using Fourier transform infrared spectroscopy [FT-IR] and found compatible with each other. The optimized batch Transfersomes were exhibit vesicle size. The optimized batch formulations of Transfersomes were incorporated in polymer and evaluated in comparison with marketed product for drug content, pH, spreadability, in vitro permeation. The deformed vesicle formed formulation exhibit better performance in combination with edge activator rather than branded formulation. Based upon the analyzed parameters such as drug release it can be concluded that transfersome formulation containing Drug provides better permeation rate in comparison to the marketed one.
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How To Cite (APA)
Mr. Vaibhavkumar Bapu Bhagwat, Mr. Kharade Rajendra Gulab, Mr. Survase Abhijeet B., & Mr. Ban Amol Ankush (March-2023). The Vesicular Transfersome: An Permeation Enhancer Carrier of Low Permeability Drug. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(3), d753-d759. https://ijnrd.org/papers/IJNRD2303397.pdf
Issue
Volume 8 Issue 3, March-2023
Pages : d753-d759
Other Publication Details
Paper Reg. ID: IJNRD_189610
Published Paper Id: IJNRD2303397
Downloads: 000122254
Research Area: Pharmacy
Author Type: Indian Author
Country: Dist-Pune, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2303397.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303397
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