Comparative Study to Assess the Efficacy of Intrapleural Corticosteroids versus Systemic Corticosteroids in the Treatment of Tubercular Pleural Effusion

Registration ID: IJNRD_189230

Published ID: IJNRD2303297

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Dr Sourabh Phutela , Dr Kiranjit , Dr Raj Kumar , Dr Kuldeep Singh , Dr Husan Pal

Tubercular pleural effusion, oral corticosteroids, intrapleural corticosteroids, residual pleural thickening

Background: Tubercular Pleural Effusion is the second most common extrapulmonary site of involvement after lymph node tuberculosis. It is basically due to the type IV hypersensitivity reaction leading to the inflammation of the pleura. The healing of effusion arises with a legacy of pleural fibrosis resulting in clinically relevant pleural thickening and impairment of lung function. Corticosteroids have been shown to play an important role in treating and preventing pleural fibrosis when used along with ATT therapy in cases of Tubercular Pleural Effusion. Commonly corticosteroids are prescribed as oral/systemic therapy. Some studies have also shown that a single dose of intrapleural application of corticosteroids reduces complications like pleural fibrosis. Thus, this study was conducted to compare the efficacy of intrapleural corticosteroids versus systemic corticosteroids in the treatment of tubercular pleural effusion. Methods: A total of 100 patients with tubercular pleural effusion who presented to the Department of Pulmonary Medicine, GGSMCH Faridkot were included in the study for one year. Using a computer-generated random number table cases were randomised into two groups, Group I and Group II. Both groups were given Anti Tubercular Treatment (ATT) Fixed Dose Combination (FDC), according to the weight band as per National Tuberculosis Elimination Program (NTEP) guidelines. In addition to ATT, Group I was given Tablet Deflazacort P.O. 0.75mg/kg/day for 6 days thereafter tapering the drug 0.6mg/kg/day for 6 days  0.45mg/kg/days for 6 days  0.3mg/kg/day for 6 days  0.15mg/kg/day for 6 days  stopped. In Group II, at the time of therapeutic aspiration, Intrapleural application of Dexamethasone 8mg, single time, was done. After this, patients of both groups were followed up at 4 weeks, 8 weeks, 12 weeks, and 24 weeks with chest x-rays and USG chest to estimate the level of pleural fluid (resolution/increase in pleural effusion) and pleural thickening (fibrosis/adhesions). Results: At the end of the study period, it was seen that a maximum of the patients (group I -- 64% and group II – 66%) showed resolution of pleural effusion during the first 8 weeks of treatment (not significant), whereas in 14% of the patients in group I and 4% in group II, pleural effusion did not resolve till the end of the study period (not significant). Residual Pleural Thickening was seen in 28% of patients in group I and 32% in group II (not significant). But more side effects of drugs were seen with oral corticosteroids (78%) than with intrapleural corticosteroids (40%) with a significant p-value. Conclusion: Keeping in view the fewer side effects of local corticosteroids, we emphasize that Intrapleural corticosteroids should be considered over Oral corticosteroids along with Anti- Tubercular Therapy in the treatment of Tubercular Pleural Effusion.

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Dr Sourabh Phutela, Dr Kiranjit, Dr Raj Kumar, Dr Kuldeep Singh, & Dr Husan Pal (March-2023). Comparative Study to Assess the Efficacy of Intrapleural Corticosteroids versus Systemic Corticosteroids in the Treatment of Tubercular Pleural Effusion. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(3), c847-c851. https://ijnrd.org/papers/IJNRD2303297.pdf

Volume 8 Issue 3, March-2023

Pages : c847-c851

Paper Reg. ID: IJNRD_189230

Published Paper Id: IJNRD2303297

Downloads: 000121986

Research Area: Health Science 

Country: FAZILKA , Punjab , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303297.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303297

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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