Formulation and Evaluation of Nanoparticles of an Antianginal Drug for Transdermal Delivery

Registration ID: IJNRD_188878

Published ID: IJNRD2303278

DOI: Click Here to Get

Pavitra malipatil , Dr.Rama bukka , Praveen s

Nanoparticles; Nifedipine; Compritol 888 ATO; Span 60; Tween 80; Optimization etc...

Solid Lipid Nanoparticles of Nifedipine were prepared by using Solvent emulsification evaporation method by using Compritol 888 ATO as Lipid, Span 60 and Tween 80 as Surfactants. The optimization was carried out using design expert software. The Central composite design (CCD) was selected to study the influence of critical formulation parameters. The prepared nanoparticles were evaluated for particle size, poly dispersity index, zeta potential, entrapment efficiency, drug content and In-vitro drug release studies using statistical methods. The particle size and entrapment efficiency of the nanoparticles was found to increase with increase in Compritol concentration and decrease in particle size with increasing tween 80. The optimized concentration for independent variables Compritol 888 ATO (X1) and Span 60/Tween 80 (X2) was found to be 2gm and 2gm respectively, with a desirability of 0.842 by Numerical optimization method. This was found to be in close agreement with the experimental response of formulation F1. It was concluded that the solid lipid nanoparticles of Nifedipine can be successfully formulated by solvent emulsification evaporation method.

Published Paper   E-Certificate

Pavitra malipatil, Dr.Rama bukka, & Praveen s (March-2023). Formulation and Evaluation of Nanoparticles of an Antianginal Drug for Transdermal Delivery. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(3), c695-c705. https://ijnrd.org/papers/IJNRD2303278.pdf

Volume 8 Issue 3, March-2023

Pages : c695-c705

Paper Reg. ID: IJNRD_188878

Published Paper Id: IJNRD2303278

Downloads: 000121978

Research Area: Pharmacy

Country: Bangalore, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303278.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303278

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 10 | October 2025

IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.

The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.

Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.

How to submit the paper?

By Our website

Click Here to Submit Paper Online

By Mail

Send your paper to editor@ijnrd.org

Important Dates for Current issue

Paper Submission Open For: October 2025

Current Issue: Volume 10 | Issue 10 | October 2025

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-Oct-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.

Subject Category: Research Area

Call for Paper: More Details