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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
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Impact Factor : 8.76

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Paper Title: Synthesis and Evaluation of Antimicrobial and Anti-inflammatory Activity of Oxadiazole Derivatives
Authors Name: RAM BABAN INGLE , MISS.K.A. DALAVI
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IJNRD_188778
Published Paper Id: IJNRD2303219
Published In: Volume 8 Issue 3, March-2023
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Abstract: The synthesis, structure and biological activity of Oxadiazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Oxadiazole derivatives have been reported to possess interesting biological activities such as Antimicrobial, Anti-inflammatory and Antifungal activities etc. In the present proposal, aromatic aldehyde was made to react with ethyl acetoacetate in presence of ammonia to yield 1, 4-dihydropyridine derivatives. 1, 4-dihydropyridine was refluxed in presence of hydrazine and ammonia to yield offer corresponding hydrazides. Hydrazide was refluxed with an aromatic acid along with addition of phosphorous to offer final compounds. All synthesized compound were characterized by IR, H¬1-NMR and elemental Analysis. All the compounds were evaluated for Antibacterial and Anti-inflammatory at the concentration of 200 µcg/mL by using cup-plate agar diffusion method. The activity was carried out on different micro-organisms (E. coli, S. aureus, A. niger, C. albicans) measured in terms of zone of inhibition and compared the standard drug Ciprofloxacin and Amphotericin B for antimicrobial activity. All the newly synthesized derivatives were screened for Anti-inflammatory activity by an in-vitro method of Inhibition of protein denaturation using Zaltoprofen as a standard. These compounds with the suitable molecular modification may prove as a drug of choice in the treatment of microbial infectious disease in future.
Keywords: Anti-inflammatory, Antimicrobial and Oxadiazole.
Cite Article: "Synthesis and Evaluation of Antimicrobial and Anti-inflammatory Activity of Oxadiazole Derivatives", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 3, page no.c130-c141, March-2023, Available :http://www.ijnrd.org/papers/IJNRD2303219.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2303219
Registration ID: 188778
Published In: Volume 8 Issue 3, March-2023
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Page No: c130-c141
Country: buldhana, maharastra, india
Research Area: Chemistry
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2303219
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2303219
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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