In-Vivo Anti-Arthritic Effect Of Combination Of Boswellic Acid, Berberine And Silymarin In Freund's Complete Adjuvant Induced Arthritis In Rats

Registration ID: IJNRD_188346

Published ID: IJNRD2303059

: http://doi.one/10.1729/Journal.34589

Shrikanta, Bhargav A, Dr. Rama Nargund, Wani Adil Rashid

Boswellic acid, berberine, silymarin and Freund’s complete adjuvant

Rheumatoid arthritis is a chronic autoimmune disease, which affects approximately 1% adult population. Boswellic acid, berberine, silymarin are major constituent of boswellia serrata, berberies aristata and milk thistle respectively and are reported to be effective as anti-inflammatory and anti-arthritic activity. The present study was undertaken to evaluate anti-arthritic activity of combination of boswellic acid, berberine, silymarin in FCA-induced arthritic rats. BBS (150 mg/kg bw p.o) was administered for 28 days and various physical (body weight, paw volume and paw thickness), haematological, biochemical and histopathological parameters were assessed. The BBS showed a significant (P<0.001) reduction in paw volume and paw thickness from the 14th to 28th day in the developing phase and reversed the haematological and biochemical parameters as compared to arthritic rats. Histological reports also suggested that histological changes reversed in BBS treated rats. BBS treatment in developed phase has shown moderate anti-arthritic effect. Present study indicated that BBS formulation has significant anti-arthritic activity and beneficial in early stage of arthritis and moderate effect in late stages. Further studies are needed to explore the underlying mechanism in molecular level.

Published Paper   E-Certificate

Shrikanta, Bhargav A, Dr. Rama Nargund, & Wani Adil Rashid (March-2023). In-Vivo Anti-Arthritic Effect Of Combination Of Boswellic Acid, Berberine And Silymarin In Freund's Complete Adjuvant Induced Arthritis In Rats. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(3), a585-a592. http://doi.one/10.1729/Journal.34589

Volume 8 Issue 3, March-2023

Pages : a585-a592

Paper Reg. ID: IJNRD_188346

Published Paper Id: IJNRD2303059

Downloads: 000122022

Research Area: Pharmacy

Author Type: Indian Author

Country: Udupi, Karnataka, India

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Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2303059

Crossref DOI: http://doi.one/10.1729/Journal.34589

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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