INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
RP-HPLC Method development and validation of Febuxostat in dosage forms RP-HPLC method was developed and validated for Febuxostat in dosage forms. The achieved by C18 (Grace) column of (4.6×250 mm) with particle size packing 5 µm and Methanol: Water (90:10) (0.05 % OPA) as mobile phase at a flow rate of 1.0 ml/min. The detection was carried out at 315 nm. The retention time of Febuxostat 5.13min. Reproducibility of the chromatographic system was adequate. Accuracy of method is ascertained by recovery studies performed at different levels of concentrations (80%, 100% and 150%). The % recovery was found to be within 97-101%. Precision studies were carried out using parameter like intra-day and inter-day Precision, the study showed that the results were within acceptance limit. i.e.% RSD below 2.0 indicating reproducibility of method. Linearity of Febuxostat was observed in the range of 10-50 μg/ml and Detection of wavelength used was 315 nm. The calibration curve yielded correlation coefficient (r2) 0.999& 0.999 for Febuxostat.
"“DEVELOPMENT & VALIDATION FOR ESTIMATION OF ANTI-HYPER URICEMIC DRUG BY RP-HPLC METHOD FROM DOSAGE FORM”", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 3, page no.a545-a584, March-2023, Available :http://www.ijnrd.org/papers/IJNRD2303058.pdf
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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