Formulation of Quinine Sulphate Microemulsifying Suppository for Better enhancement.

Registration ID: IJNRD_188258

Published ID: IJNRD2303038

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Tejas.R, Beny Baby, S.Rajarajan

Microemulsion, Suppository, Quininesulphate and Antimalarial

Malaria, a parasitic infection, causes many voluminous illness episodes and a large number of deaths on an annual basis, nearly all of them occurring within the poorer and a lot of vulnerable sectors of the world's developing countries. Despite the enormous burden of suffering caused by malaria, the human rights implications of this ill health have not been clearly outlined. The microemulsion is prepared using a phase titration method and the suitable drug is added to the microemulsion, the resultant microemulsion with cocoa butter melt drug is poured into the suppository mould to form suppositories using the fusion moulding method. The optimized formulation of the microemulsion was prepared using the special cubic model and the microemulsion was evaluated for different physicochemical evaluation, invitro drug release, globule size, and % transmittance. Results of quinine sulphate microemulsion revealed that clear solution obtained for Microemulsion S mix ratio (1:1) oil: S mix ratio (8:2). The microemulsion ME6 shows better 98.63 % of drug release, 95.48 % of transmittance, globule size of 208 nm. The optimized formulation ME10 shows 95.146% of drug release, 97.001% of transmittance and a globule size of 219.56nm. All the formulation (MES1- MES6) micro emulsifying suppositories evaluated showed comparable dissolution & drug release results with MES4 is best, since 98.75% of drug dissolved in 30 min in dissolution studies and 90.38% of drug released in 6 hours in diffusion studies. The current study intends to develop self-microemulsifying quinine sulphate suppositories for the medication of malaria with an earlier onset of action and more lasting effect.

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Tejas.R, Beny Baby, & S.Rajarajan (March-2023). Formulation of Quinine Sulphate Microemulsifying Suppository for Better enhancement.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(3), a368-a388. https://ijnrd.org/papers/IJNRD2303038.pdf

Volume 8 Issue 3, March-2023

Pages : a368-a388

Paper Reg. ID: IJNRD_188258

Published Paper Id: IJNRD2303038

Downloads: 000122015

Research Area: Pharmacy

Author Type: Indian Author

Country: Bangalore rural district, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2303038.pdf

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