SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL HYDANTOIN DERIVATIVES

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL HYDANTOIN DERIVATIVES

Registration ID: IJNRD_187799

Published ID: IJNRD2302279

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YASHRAJ JOSHI , Mehta Parulben D , Dr. KAUSHELENDRA MISHRA

hydantoin, benzaldehyde , antimicrobial activity, antibacterial activity.

New compounds were synthesized containing novel hydantoin derivatives and tested for their antimicrobial activity against gram positive and gram negative strains. The scheme was adopted for the synthesis of hydantoin derivatives was Bucherer-Bergs method. In this method, firstly benzoin was prepared by the pinacol-pinacolone rearrangement reaction of benzaldehyde with thiamine which was then reacted with concentrated HNO3 to form benzil and then it was further reacted with urea. Total five compounds were synthesized and characterization was done using various physical and spectral techniques such as Thin Layer Chromatography, Melting point ,Solubility determination, UV spectroscopy and FTIR spectroscopy and 1HNMR spectroscopy. All the synthesized compounds were biologically evaluated for in-vitro antimicrobial activity against gram positive and gram negative bacteria by well diffusion method. The bacterias chosen was Bacillus subtilis for gram positive and Proteus vulgaris for gram-negative. The antibacterial assay was performed for all the synthesized compounds at different concentrations and compared with standard with single concentration ranging 100μg/ml against microorganism. The antibacterial activity of hydantoin derivatives showed the significant zone of inhibition against, Bacillus subtilis and Proteus vulgaris. Thus from the study it is concluded that these new hydration derivatives could serve as effective antimicrobial agents.

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"SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL HYDANTOIN DERIVATIVES", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 2, page no.c714-c719, February-2023, Available :https://ijnrd.org/papers/IJNRD2302279.pdf

Volume 8 Issue 2, February-2023

Pages : c714-c719

Paper Reg. ID: IJNRD_187799

Published Paper Id: IJNRD2302279

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Research Area: Engineering

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Published Paper PDF: https://ijnrd.org/papers/IJNRD2302279.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302279

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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