INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
New compounds were synthesized containing novel hydantoin derivatives and tested for their antimicrobial activity against gram positive and gram negative strains. The scheme was adopted for the synthesis of hydantoin derivatives was Bucherer-Bergs method. In this method, firstly benzoin was prepared by the pinacol-pinacolone rearrangement reaction of benzaldehyde with thiamine which was then reacted with concentrated HNO3 to form benzil and then it was further reacted with urea. Total five compounds were synthesized and characterization was done using various physical and spectral techniques such as Thin Layer Chromatography, Melting point ,Solubility determination, UV spectroscopy and FTIR spectroscopy and 1HNMR spectroscopy. All the synthesized compounds were biologically evaluated for in-vitro antimicrobial activity against gram positive and gram negative bacteria by well diffusion method. The bacterias chosen was Bacillus subtilis for gram positive and Proteus vulgaris for gram-negative. The antibacterial assay was performed for all the synthesized compounds at different concentrations and compared with standard with single concentration ranging 100μg/ml against microorganism. The antibacterial activity of hydantoin derivatives showed the significant zone of inhibition against, Bacillus subtilis and Proteus vulgaris. Thus from the study it is concluded that these new hydration derivatives could serve as effective antimicrobial agents.
"SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL HYDANTOIN DERIVATIVES", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.c714-c719, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302279.pdf
Downloads:
000118755
ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Facebook Twitter Instagram LinkedIn