SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL PHENOTHIAZINE DERIVATIVES

SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL PHENOTHIAZINE DERIVATIVES

Registration ID: IJNRD_187798

Published ID: IJNRD2302278

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Ritu Joshi , Mehta Parulben , Dr. Shivakant Shukla

phenothiazine, diphenylamine , antimicrobial activity, antibacterial activity.

New compounds were synthesized containing novel hydantoin derivatives and tested for their antimicrobial activity against gram positive and gram negative strains. The scheme was adopted for the synthesis of phenothiazine derivatives is done via thionation of aryl amines. Total five compounds were synthesized and characterization was done using various physical and spectral techniques such as Thin Layer Chromatography, Melting point ,Solubility determination, UV spectroscopy and FTIR spectroscopy and 1HNMR spectroscopy. All the synthesized compounds were biologically evaluated for in-vitro antimicrobial activity against gram positive and gram negative bacteria by well diffusion method. The in-vitro evaluation of the synthesized compounds was performed by taking gram positive bacteria Staphylococcus Aureus and gram negative bacteria Escherichia Coli. The antibacterial activity of phenothiazine derivatives showed significant zone of inhibition against both bacterias. Thus from the study it is concluded that these new hydration derivatives could serve as effective antimicrobial agents.

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"SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL PHENOTHIAZINE DERIVATIVES", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 2, page no.c708-c713, February-2023, Available :https://ijnrd.org/papers/IJNRD2302278.pdf

Volume 8 Issue 2, February-2023

Pages : c708-c713

Paper Reg. ID: IJNRD_187798

Published Paper Id: IJNRD2302278

Downloads: 000121165

Research Area: Engineering

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Published Paper PDF: https://ijnrd.org/papers/IJNRD2302278.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302278

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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