SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL PHENOTHIAZINE DERIVATIVES

Registration ID: IJNRD_187798

Published ID: IJNRD2302278

DOI: Click Here to Get

Ritu Joshi , Mehta Parulben , Dr. Shivakant Shukla

phenothiazine, diphenylamine , antimicrobial activity, antibacterial activity.

New compounds were synthesized containing novel hydantoin derivatives and tested for their antimicrobial activity against gram positive and gram negative strains. The scheme was adopted for the synthesis of phenothiazine derivatives is done via thionation of aryl amines. Total five compounds were synthesized and characterization was done using various physical and spectral techniques such as Thin Layer Chromatography, Melting point ,Solubility determination, UV spectroscopy and FTIR spectroscopy and 1HNMR spectroscopy. All the synthesized compounds were biologically evaluated for in-vitro antimicrobial activity against gram positive and gram negative bacteria by well diffusion method. The in-vitro evaluation of the synthesized compounds was performed by taking gram positive bacteria Staphylococcus Aureus and gram negative bacteria Escherichia Coli. The antibacterial activity of phenothiazine derivatives showed significant zone of inhibition against both bacterias. Thus from the study it is concluded that these new hydration derivatives could serve as effective antimicrobial agents.

Published Paper   E-Certificate

Ritu Joshi, Mehta Parulben , & Dr. Shivakant Shukla (February-2023). SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NOVEL PHENOTHIAZINE DERIVATIVES. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(2), c708-c713. https://ijnrd.org/papers/IJNRD2302278.pdf

Volume 8 Issue 2, February-2023

Pages : c708-c713

Paper Reg. ID: IJNRD_187798

Published Paper Id: IJNRD2302278

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Research Area: Engineering

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