FORMULATION AND EVALUATION OF FLOATING MICROBALLOONS OF ALLOPURINOL

Registration ID: IJNRD_187938

Published ID: IJNRD2302273

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Prachi Gohil

Floating, microparticulate, hollow sphere, allopurinol

To formulate physically and chemically sustained release formulation of allopurinol by using a gastro retentive drug delivery system with the floating approach. Sustained release floating microballoons containing allopurinol was formulated by solvent evaporation method with sustained release polymer, DCM and ethanol as organic solvents and tween 80 as a processing medium by using 32 factorial designs. The independent factors were concentration of Eudragit RS 100 and tween 80 whereas dependent factors were % entrapment efficiency and % drug release. The prepared batches were evaluated for particle size, % entrapment efficiency, drug loading, floating time, total floating time and in-vitro drug release. During experiment the concentration of polymer increases shows decrease in entrapment, drug release and also affect the floating property. Thus, in moderate concentration of polymer shows excellent result of % entrapment efficiency, % drug release, floating property and sustained drug delivery. Evaluations were performed for optimized batch (B3) shows 1.04 seconds floating time, 97.45% drug entrapment efficiency, 98.19% drug release at 12 hours and total floating time up to 12hours. The sustained release floating microballoons system is a promising novel drug delivery system for the treatment of gout using allopurinol as a drug. This system is used because it enhances the floating behavior at upper part of GIT as microballoons have low density and hollow space, also the drug has solubility on upperpart of GIT

Published Paper   E-Certificate

Prachi Gohil (February-2023). FORMULATION AND EVALUATION OF FLOATING MICROBALLOONS OF ALLOPURINOL. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(2), c657-c665. https://ijnrd.org/papers/IJNRD2302273.pdf

Volume 8 Issue 2, February-2023

Pages : c657-c665

Paper Reg. ID: IJNRD_187938

Published Paper Id: IJNRD2302273

Downloads: 000122253

Research Area: Pharmacy

Author Type: Indian Author

Country: Vadodara, Gujarat, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2302273.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302273

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