“SYNTHESIS AND SOLUBILITY ENHANCEMENT OF PHENYTOIN BY SOLID DISPERSION USING VARIOUS POLYMERS

Registration ID: IJNRD_187910

Published ID: IJNRD2302261

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Karishma Sharma , Komal Pawar , Shital Patil , Laxman Patil

solid dispersion, poorly water soluble, hydrophilic polymers

The present study was undertaken to synthesized phenytoin using benzil and urea by using microwave synthesizer and solid dispersion of phenytoin was prepared using with different carriers such as PEG -6000, PVPK-30 and D – Mannitol bythe solvent evaporation method for increasing dissolution rate and bioavailability of the drug. Polymers used in solid dispersion techniques are hydrophilic in nature and compatible with drug to enhance drug dissolution rate. These different ratios of solid dispersion were characterized by UV spectroscopy for saturated solubility and dissolution study and it was observed that and dissolution rate was enhanced in the ratio of PEG -6000 (1:3) as compared to other ratios of other carriers

Published Paper   E-Certificate

Karishma Sharma, Komal Pawar, Shital Patil, & Laxman Patil (February-2023). “SYNTHESIS AND SOLUBILITY ENHANCEMENT OF PHENYTOIN BY SOLID DISPERSION USING VARIOUS POLYMERS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(2), c513-c522. https://ijnrd.org/papers/IJNRD2302261.pdf

Volume 8 Issue 2, February-2023

Pages : c513-c522

Paper Reg. ID: IJNRD_187910

Published Paper Id: IJNRD2302261

Downloads: 000121981

Research Area: Pharmacy

Country: Hyderabad, Telagana, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2302261.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302261

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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