DIAGNOSIS OF PRIMARY MYELOFIBROSIS PRE-FIBROTIC PHASE-(A Rare case report)

Registration ID: IJNRD_187843

Published ID: IJNRD2302253

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Dr.G K Parvathidevi, Dr.Ramesh S T

myelofibrosis,myeloproliferative,neoplasm

Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm (MPN) characterized by a proliferation of prodominently megakaryocytes and granulocytes in the bone marrow that in fully developed disease is associated with reactive deposition of fibrous connective tissue and with extramedullary haematopoiesis(EMF)(1). There is a stepwise evolution from an initial pre-fibrotic phase charecterised by a hypercellular marrow with absent or minimal reticulin fibrosis to a fibrotic phase with marked reticulin collagen fibrosis in the marrowand often sclerosis.  The synonyms for PMF include- Chronic idiopathic myelofirbosis (CIMF); Agnogenic myeloid metaplasia (AMM); Myelofibrosis /sclerosis with myeloid metaplasia (MMM); Idiopathic myelofibrosis; Myeloid megakaryocytic granulocytic metaplasia (MMGM); and many others(2). Literature search revealed three study groups comprising of 1247 cases of pre-fibrotic phase of primay myelobrosis (3,4,5). We could not find any single case reports. We report here the peripheral smear findings,bone marrow examination findings, cytogenetic abnormality in a case of prefibrotic phase of primary myelofibrosis in a 70 year old male patient, who presented with pain abdomen.

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Dr.G K Parvathidevi & Dr.Ramesh S T (February-2023). DIAGNOSIS OF PRIMARY MYELOFIBROSIS PRE-FIBROTIC PHASE-(A Rare case report). INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(2), c459-c472. https://ijnrd.org/papers/IJNRD2302253.pdf

Volume 8 Issue 2, February-2023

Pages : c459-c472

Paper Reg. ID: IJNRD_187843

Published Paper Id: IJNRD2302253

Downloads: 000122255

Research Area: Health Science 

Author Type: Indian Author

Country: Tumkur, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2302253.pdf

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