INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Primary myelofibrosis (PMF) is a clonal myeloproliferative neoplasm (MPN) characterized by a proliferation of prodominently megakaryocytes and granulocytes in the bone marrow that in fully developed disease is associated with reactive deposition of fibrous connective tissue and with extramedullary haematopoiesis(EMF)(1). There is a stepwise evolution from an initial pre-fibrotic phase charecterised by a hypercellular marrow with absent or minimal reticulin fibrosis to a fibrotic phase with marked reticulin collagen fibrosis in the marrowand often sclerosis.
The synonyms for PMF include- Chronic idiopathic myelofirbosis (CIMF); Agnogenic myeloid metaplasia (AMM); Myelofibrosis /sclerosis with myeloid metaplasia (MMM); Idiopathic myelofibrosis; Myeloid megakaryocytic granulocytic metaplasia (MMGM); and many others(2).
Literature search revealed three study groups comprising of 1247 cases of pre-fibrotic phase of primay myelobrosis (3,4,5). We could not find any single case reports. We report here the peripheral smear findings,bone marrow examination findings, cytogenetic abnormality in a case of prefibrotic phase of primary myelofibrosis in a 70 year old male patient, who presented with pain abdomen.
Keywords:
myelofibrosis,myeloproliferative,neoplasm
Cite Article:
"DIAGNOSIS OF PRIMARY MYELOFIBROSIS PRE-FIBROTIC PHASE-(A Rare case report)", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.c459-c472, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302253.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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