Paper Title
Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-kB and MAPK signalling
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Registration ID: IJNRD_187636
Published ID: IJNRD2302192
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Keywords
sepsis, losartan, monocytes, myocardial injury, inflammation
Abstract
Sepsis- conviced cardiomyopathy (SIC) is a serious complication of sepsis with high mortality but no effective treatment. The renin angiotensin( Ang) aldosterone system( RAAS) is actuated in cases with sepsis but it's unclear how the Ang II/ Ang II type 1 receptor( AT1R) axis contributes to SIC. This study examined the link between the Ang II/ AT1R axis and SIC as well as the defensive effect of AT1R blockers( ARBs). The Ang II position in supplemental tube and AT1R expression on monocytes were significantly advanced in cases with SIC compared with those innon- SIC cases and healthy controls and were linked with the degree of myocardial injury. The ARB losartan reduced the infiltration of neutrophils, monocytes, and macrophages into the heart and spleen of SIC mice. also, losartan regulated macrophage polarization from the M1 to the M2 subtype via nuclear factor- kappa B( NF- κB) and mitogen- actuated protein kinase( MAPK) signaling pathways, thereby maintaining the mitochondrial dynamics balance in cardiomyocytes and reducing oxidative stress and cardiomyocyte apoptosis. In conclusion, the tube Ang II position and AT1R expression on tube monocytes are an important biomarker in SIC. remedial targeting of AT1R, for illustration with losartan, can potentially cover against myocardial injury in SIC.
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How To Cite (APA)
Shahin Shahabuddin Attar, Komal Narayan Gavalkar, & Dipak Sopan Nandurkar (February-2023). Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-kB and MAPK signalling. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(2), b884-b888. https://ijnrd.org/papers/IJNRD2302192.pdf
Issue
Volume 8 Issue 2, February-2023
Pages : b884-b888
Other Publication Details
Paper Reg. ID: IJNRD_187636
Published Paper Id: IJNRD2302192
Research Area: Pharmacy
Author Type: Indian Author
Country: satara, maharastra, india
Published Paper PDF: https://ijnrd.org/papers/IJNRD2302192.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302192
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