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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-kB and MAPK signalling |
| Authors Name: | Shahin Shahabuddin Attar , Komal Narayan Gavalkar , Dipak Sopan Nandurkar |
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| Author Reg. ID: |
IJNRD_187636
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| Published Paper Id: | IJNRD2302192 |
| Published In: | Volume 8 Issue 2, February-2023 |
| DOI: | |
| Abstract: | Sepsis- conviced cardiomyopathy (SIC) is a serious complication of sepsis with high mortality but no effective treatment. The renin angiotensin( Ang) aldosterone system( RAAS) is actuated in cases with sepsis but it's unclear how the Ang II/ Ang II type 1 receptor( AT1R) axis contributes to SIC. This study examined the link between the Ang II/ AT1R axis and SIC as well as the defensive effect of AT1R blockers( ARBs). The Ang II position in supplemental tube and AT1R expression on monocytes were significantly advanced in cases with SIC compared with those innon- SIC cases and healthy controls and were linked with the degree of myocardial injury. The ARB losartan reduced the infiltration of neutrophils, monocytes, and macrophages into the heart and spleen of SIC mice. also, losartan regulated macrophage polarization from the M1 to the M2 subtype via nuclear factor- kappa B( NF- κB) and mitogen- actuated protein kinase( MAPK) signaling pathways, thereby maintaining the mitochondrial dynamics balance in cardiomyocytes and reducing oxidative stress and cardiomyocyte apoptosis. In conclusion, the tube Ang II position and AT1R expression on tube monocytes are an important biomarker in SIC. remedial targeting of AT1R, for illustration with losartan, can potentially cover against myocardial injury in SIC. |
| Keywords: | sepsis, losartan, monocytes, myocardial injury, inflammation |
| Cite Article: | "Losartan attenuates sepsis-induced cardiomyopathy by regulating macrophage polarization via TLR4-mediated NF-kB and MAPK signalling", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.b884-b888, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302192.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2302192 Registration ID: 187636 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: b884-b888 Country: satara, maharastra, india Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2302192 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2302192 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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