A REVIEW: DRUG- EXCIPIENT INTERACTIONS STUDY

A REVIEW: DRUG- EXCIPIENT INTERACTIONS STUDY

Registration ID: IJNRD_187576

Published ID: IJNRD2302162

DOI: Click Here to Get

Mr. Shiddesh D. Gawari , Ms.Sonali B. Jadhav , Dr. Hemant V. Kambale , Dr. Vivek M. Satpute , Santosh A. Waghmare

Excipient, Drug, Interaction, Physical, Chemical

Excipients are included in dosage forms to aid manufacture, administration or absorption. Although considered pharmacologically inert, excipients can initiate, propagate or participate in chemical or physical interactions with drug compounds, which may compromise the effectiveness of a medication. Exicipients are not exquisitely pure. Even for the most commonly used excipients, it is necessary to understand the context of their manufacture in order to identify potential active pharmaceutical ingredients interactions with trace components. Chemical interactions can lead to degradation of the active ingredient, thereby reducing the amount available for therapeutic effect. Physical interactions can affect rate of dissolution, uniformity of dose or ease of administration. Understanding the chemical and physical nature of excipients, the impurities or residues associated with them and how they may interact with other materials, or with each other, forewarns the pharmaceutical technologist of possibilities for undesirable developments. The potential physical and chemical interactions between drugs and excipients can affect the chemical, physical, therapeutical properties and stability of the dosage form. The present review contains a basic mode of drug degradation, mechanism of drug- excipient interaction like physical, chemical and biopharmaceutical. Different Thermal and Non-thermal method of analysis, Tools and software for incompatibility is also discussed. Once the type of interaction is determined we can take further steps to improve the stability of drug and dosage form. From review, we conclude that consequent use of thermal and non-thermal method provide data for drug- excipient interaction which can further help in selection of excipient for the development of stable dosage form.

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"A REVIEW: DRUG- EXCIPIENT INTERACTIONS STUDY", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 2, page no.b641-b651, February-2023, Available :https://ijnrd.org/papers/IJNRD2302162.pdf

Volume 8 Issue 2, February-2023

Pages : b641-b651

Paper Reg. ID: IJNRD_187576

Published Paper Id: IJNRD2302162

Downloads: 000121245

Research Area: Pharmacy

Country: ahmednagar, maharashatra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2302162.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302162

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

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