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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | A REVIEW: SOLUBILITY ENHANCEMENT TECHNIQUE |
| Authors Name: | Abhishek Yadav , Nitesh Devvanshi , Ashutosh Kumar Yadav , Shweta Mishra |
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| Author Reg. ID: |
IJNRD_187426
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| Published Paper Id: | IJNRD2302121 |
| Published In: | Volume 8 Issue 2, February-2023 |
| DOI: | |
| Abstract: | The solubility is amount of solute which is dissolved in solvent to form a solution below a particular situation of gravity / pressure and temperature. But mainly the API (Active pharmaceutical ingredient) are poorly aqueous soluble (hydrophobic). The solubility, property of the drug becomes one of the most challenging aspect in the formulation development. Poor aqueous solubility may result in the finishing of final product and can result in decrease in its full potential and therapeutical range. Hence improvement of aqueous solubility in such a case is valuable goal to improve therapeutical efficacy. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. The API / usable pharmaceuticals with poor solubility must be answered well by solubilization techniques such as chemical modification such as salt formation, co-crystallization and more, physical modification such as conventional method, modification of the crystal habit such as polymorphs, complexation such as physical mixture and more, Inclusion complex formulation base techniques such as kneading method and more, solubilization by surfactants such as self emulsifying drug delivery systemand more, drug dispersion in carries such as solid solutions and more, pH adjustment, supercritical fluid process, liquisolid technique, and polymeric alteration. The contribution of this article is to combine all the techniques which can enhance the solubility of drug. |
| Keywords: | Solubility, Bioavailability |
| Cite Article: | "A REVIEW: SOLUBILITY ENHANCEMENT TECHNIQUE", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 2, page no.b182-b205, February-2023, Available :http://www.ijnrd.org/papers/IJNRD2302121.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2302121 Registration ID: 187426 Published In: Volume 8 Issue 2, February-2023 DOI (Digital Object Identifier): Page No: b182-b205 Country: Azamgarh, Uttar pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2302121 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2302121 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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