A REVIEW: SOLUBILITY ENHANCEMENT TECHNIQUE

Registration ID: IJNRD_187426

Published ID: IJNRD2302121

DOI: Click Here to Get

Abhishek Yadav , Nitesh Devvanshi , Ashutosh Kumar Yadav , Shweta Mishra

Solubility, Bioavailability

The solubility is amount of solute which is dissolved in solvent to form a solution below a particular situation of gravity / pressure and temperature. But mainly the API (Active pharmaceutical ingredient) are poorly aqueous soluble (hydrophobic). The solubility, property of the drug becomes one of the most challenging aspect in the formulation development. Poor aqueous solubility may result in the finishing of final product and can result in decrease in its full potential and therapeutical range. Hence improvement of aqueous solubility in such a case is valuable goal to improve therapeutical efficacy. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. The API / usable pharmaceuticals with poor solubility must be answered well by solubilization techniques such as chemical modification such as salt formation, co-crystallization and more, physical modification such as conventional method, modification of the crystal habit such as polymorphs, complexation such as physical mixture and more, Inclusion complex formulation base techniques such as kneading method and more, solubilization by surfactants such as self emulsifying drug delivery systemand more, drug dispersion in carries such as solid solutions and more, pH adjustment, supercritical fluid process, liquisolid technique, and polymeric alteration. The contribution of this article is to combine all the techniques which can enhance the solubility of drug.

Published Paper   E-Certificate

Abhishek Yadav, Nitesh Devvanshi, Ashutosh Kumar Yadav, & Shweta Mishra (February-2023). A REVIEW: SOLUBILITY ENHANCEMENT TECHNIQUE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(2), b182-b205. https://ijnrd.org/papers/IJNRD2302121.pdf

Volume 8 Issue 2, February-2023

Pages : b182-b205

Paper Reg. ID: IJNRD_187426

Published Paper Id: IJNRD2302121

Downloads: 000121993

Research Area: Pharmacy

Country: Azamgarh, Uttar pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2302121.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302121

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 10 | October 2025

IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.

The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.

Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.

How to submit the paper?

By Our website

Click Here to Submit Paper Online

By Mail

Send your paper to editor@ijnrd.org

Important Dates for Current issue

Paper Submission Open For: October 2025

Current Issue: Volume 10 | Issue 10 | October 2025

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-Oct-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.

Subject Category: Research Area

Call for Paper: More Details