A REVIEW: SOLUBILITY ENHANCEMENT TECHNIQUE

A REVIEW: SOLUBILITY ENHANCEMENT TECHNIQUE

Registration ID: IJNRD_187426

Published ID: IJNRD2302121

DOI: Click Here to Get

Abhishek Yadav , Nitesh Devvanshi , Ashutosh Kumar Yadav , Shweta Mishra

Solubility, Bioavailability

The solubility is amount of solute which is dissolved in solvent to form a solution below a particular situation of gravity / pressure and temperature. But mainly the API (Active pharmaceutical ingredient) are poorly aqueous soluble (hydrophobic). The solubility, property of the drug becomes one of the most challenging aspect in the formulation development. Poor aqueous solubility may result in the finishing of final product and can result in decrease in its full potential and therapeutical range. Hence improvement of aqueous solubility in such a case is valuable goal to improve therapeutical efficacy. Molecules that would have highly beneficial effect on their physiological target would not be further developed if their bioavailability is limited by their solubility in water. The API / usable pharmaceuticals with poor solubility must be answered well by solubilization techniques such as chemical modification such as salt formation, co-crystallization and more, physical modification such as conventional method, modification of the crystal habit such as polymorphs, complexation such as physical mixture and more, Inclusion complex formulation base techniques such as kneading method and more, solubilization by surfactants such as self emulsifying drug delivery systemand more, drug dispersion in carries such as solid solutions and more, pH adjustment, supercritical fluid process, liquisolid technique, and polymeric alteration. The contribution of this article is to combine all the techniques which can enhance the solubility of drug.

Published Paper   E-Certificate

"A REVIEW: SOLUBILITY ENHANCEMENT TECHNIQUE", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 2, page no.b182-b205, February-2023, Available :https://ijnrd.org/papers/IJNRD2302121.pdf

Volume 8 Issue 2, February-2023

Pages : b182-b205

Paper Reg. ID: IJNRD_187426

Published Paper Id: IJNRD2302121

Downloads: 000121203

Research Area: Pharmacy

Country: Azamgarh, Uttar pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2302121.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302121

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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