FORMULATION AND INVITRO EVALUATION OF BISPROLAL FUMARATE BUCCAL FILMS

FORMULATION AND INVITRO EVALUATION OF BISPROLAL FUMARATE BUCCAL FILMS

Registration ID: IJNRD_186147

Published ID: IJNRD2302039

DOI: Click Here to Get

PAVAN I SURE , M.ANUSHA , NAFEES FATIMA

Key words :Beta-blockers,Patches,Buccal delivery,Bisoprolol.

Bisoprolol is a drug belonging to the group of beta-blockers, a class of medicines used primarily in cardiovascular diseases. More specifically, it is a selective type β1 adrenergic receptor blocker. The U.S. Food and Drug Administration (FDA) approved an application by Duramed Pharmaceutical for Zebeta Oral Tablets (bisoprolol fumarate) as a new molecular entity on July 31, 1992. In current work buccal drug delivery of Bisoprolol was developed to overcome the first pass metabolism and to reduce frequency of dosing compared to oral route. buccal patches was prepared by using polymers Eudragit-L100, HPMCk4M and HPMCk15M. by employing solvent casting method. Propylene glycol and Tween80 were selected as permeation enhancer and plasticizer. all the formulations prepare (F1-F9)were evaluated for various physical parameters Physical appearance, Flatness, Weight variation, Thickness, Folding endurance, Drug content, Moisture uptake, Moisture content and Swelling study and all the results were found to be were found to be with in the pharmacopeial limits, invitro drug release studies by using dialysis membrane. Among all the 9 formulations F6 formulation which contain HPMC K4M 300mg and Eudragit L-100 60mg had shown 94% cumulative drug release with in 12 hours. And compared to HPMC K15M, HPMC K4M showed better drug release profile. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there were no interactions. Key words :Beta-blockers,Patches,Buccal delivery,Bisoprolol.

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"FORMULATION AND INVITRO EVALUATION OF BISPROLAL FUMARATE BUCCAL FILMS", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 2, page no.a306-a317, February-2023, Available :https://ijnrd.org/papers/IJNRD2302039.pdf

Volume 8 Issue 2, February-2023

Pages : a306-a317

Paper Reg. ID: IJNRD_186147

Published Paper Id: IJNRD2302039

Downloads: 000121131

Research Area: Pharmacy

Country: Hyderabad, telangana, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2302039.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2302039

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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