Review On Novel Approach Of Okra Gum

Registration ID: IJNRD_186508

Published ID: IJNRD2301275

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Miss. Takawane Swamini , Miss. Gupta Poonam , Miss. Deshmukh Kadambari, Miss, Landge Akshata, Mr. Siddheshwar Patole

Binder, Control release, Drug delivery, Gum, Okro

The effectiveness of Okra gum in sustaining the release of propranolol hydrochloride in a tablet was studied. Okra gum was extracted from the pods of Hibiscus esculentus using acetone as a drying agent. Dried Okra gum was made into powder form and its physical and chemical characteristics such as solubility, pH, moisture content, viscosity, morphology study using SEM, infrared study using FTIR, crystallinity study using XRD, and thermal study using DSC and TGA were carried out. The powder was used in the preparation of tablet using granulation and compression methods. Propranolol hydrochloride was used as a model drug and the activity of Okra gum as a binder was compared by preparing tablets using a synthetic and a semisynthetic binder which are hydroxylmethylpropyl cellulose (HPMC) and sodium alginate, respectively. Evaluation of drug release kinetics that was attained from dissolution studies showed that Okra gum retarded the release up to 24 hours and exhibited the longest release as compared to HPMC and sodium alginate. The tensile and crushing strength of tablets was also evaluated by conducting hardness and friability tests. Okra gum was observed to produce tablets with the highest hardness value and lowest friability. Hence, Okra gum was testified as an effective adjuvant to produce favourable sustained release tablets with strong tensile and crushing strength. Binders constitute a major class of excipients that are used to hold the active pharmaceutical ingredients and other inactive ingredients together in a cohesive mass during granulation. The type and concentration of a binder influences the physicochemical characteristics of a compressed tablet. The aim of this study therefore is to examine and compare the binding and release properties of okra gum with those of microcrystalline cellulose (Avicel) and acacia gum in erythromycin stearate tablet dosage form. Okra gum was extracted from the pods of locally cultivated Hibiscus esculentus in Okada Town. Unripe okra fruits were purchased from Edo State, Nigeria. The dried okra gum was then milled and sieved into fine powder form and evaluated for angle of repose, flow rate, solubility, pH and viscosity. The gum powder was used as a binder in the formulation of tablets using wet granulation and compression methods.

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Miss. Takawane Swamini , Miss. Gupta Poonam , Miss. Deshmukh Kadambari, Miss, Landge Akshata, & Mr. Siddheshwar Patole (January-2023). Review On Novel Approach Of Okra Gum. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(1), c548-c562. https://ijnrd.org/papers/IJNRD2301275.pdf

Volume 8 Issue 1, January-2023

Pages : c548-c562

Paper Reg. ID: IJNRD_186508

Published Paper Id: IJNRD2301275

Research Area: Engineering

Author Type: Foreign Author

Country: -, -, -

Published Paper PDF: https://ijnrd.org/papers/IJNRD2301275.pdf

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