Carbonic Anhydrase Inhibitors: Docking, Synthesis and Evaluation of Sulfonamide bearing Amino-Acid as CAII Inhibitors

Registration ID: IJNRD_186310

Published ID: IJNRD2301231

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Mrs. Darshana Shrivastava , Dr. Meena Tiwari , Diksha Gawshinde

Abstract A set of twelve of p-amino benzene sulfonamides derivatives containing amino acids were synthesized. The synthesized compounds were characterized and tested for their bCA II inhibitory activity, taking acetazolamide as standard. The percentage of bCAII inhibitory activity of the synthesized compounds ranged from 20-78 at a concentration of 0.1*103µm. The highest inhibition was shown by compound D2 (78.53) which is comparable to acetazolamide (78.62). The lowest inhibition was shown by compound D9 (20.02) respectively. Docking analysis of the synthesized compounds was also performed using GOLD software. The PDB ID 4HT0 was selected for docking studies. All the synthesized compounds show same interaction of nitrogen (N1 and N2) atoms with Zn2+, Oxygen atom of SO2 forms H- bonding with Thr forming tetrahedral geometry. The distance between the nitrogen (N1and N2) atoms and Zn2+ in the synthesized compounds is similar to that of distance between the nitrogen (N1andN2) atoms and Zn2+ found in standard drug acetazolamide.

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Mrs. Darshana Shrivastava, Dr. Meena Tiwari, & Diksha Gawshinde (January-2023). Carbonic Anhydrase Inhibitors: Docking, Synthesis and Evaluation of Sulfonamide bearing Amino-Acid as CAII Inhibitors. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(1), c224-c232. https://ijnrd.org/papers/IJNRD2301231.pdf

Volume 8 Issue 1, January-2023

Pages : c224-c232

Paper Reg. ID: IJNRD_186310

Published Paper Id: IJNRD2301231

Downloads: 000121990

Research Area: Medical Science

Country: Bhopal, madhya pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2301231.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2301231

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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