Paper Title
Low levels of vitamin D linked to poor cognitive function in older adults
Article Identifiers
: Authors
Keywords
Key words: Vitamin D deficiency, Cognitive function , Older adults, Dementia, 25-hydroxyvitamin D.
Abstract
Abstract: The objective of this study was to review the association of vitamin D with age-related cognitive impairment. Vitamin D is actually a neuroactive steroid produced endogenously that acts on brain development, leading to alterations in brain neurochemistry and adult brain function which directly or indirectly regulates thousands of genes acting mainly via the vitamin D receptor. Vitamin D receptors are widespread in brain tissue. Vitamin D’s biologically active form [1,25(OH)2D] has shown neuroprotective effects on integrity of neurons by detoxification routes, anti-inflammatory effects and neurotropic synthesis, also associated with reduced β-amyloid plaques, a hallmark of Alzheimer’s disease. In older adults, the integrity of the skin decreases with aging. Skin thinning and transdermal cholesterol decreases the efficiency of UVB vitamin D production by up to 50% compared to younger adults. Lower levels of vitamin D were repeatedly found to be associated with worse memory performance, executive dysfunction and overall impaired cognitive functioning in older adults. The risk of cognitive impairment was up to 4 times greater in the severely deficient elders ([25(OH)D] <25nmol/L) in comparison with individuals with adequate levels (>75nmol/L). Even if vitamin D levels of patients with severe vitamin D deficiency were increased to an adequate level, the cognitive performance of patients did not reach to the cognitive performance of patients whose vitamin D levels were adequate from the beginning.
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How To Cite (APA)
Salma sultana shaik, Sirisha Jonna, & Dr. G. Kiran (January-2023). Low levels of vitamin D linked to poor cognitive function in older adults . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(1), c131-c136. https://ijnrd.org/papers/IJNRD2301217.pdf
Issue
Volume 8 Issue 1, January-2023
Pages : c131-c136
Other Publication Details
Paper Reg. ID: IJNRD_186213
Published Paper Id: IJNRD2301217
Downloads: 000122253
Research Area: Pharmacy
Author Type: Indian Author
Country: Narasaraopet, Guntur, Andhra Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2301217.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2301217
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