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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Low levels of vitamin D linked to poor cognitive function in older adults |
| Authors Name: | Salma sultana shaik , Sirisha Jonna , Dr. G. Kiran |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_186213
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| Published Paper Id: | IJNRD2301217 |
| Published In: | Volume 8 Issue 1, January-2023 |
| DOI: | |
| Abstract: | Abstract: The objective of this study was to review the association of vitamin D with age-related cognitive impairment. Vitamin D is actually a neuroactive steroid produced endogenously that acts on brain development, leading to alterations in brain neurochemistry and adult brain function which directly or indirectly regulates thousands of genes acting mainly via the vitamin D receptor. Vitamin D receptors are widespread in brain tissue. Vitamin D’s biologically active form [1,25(OH)2D] has shown neuroprotective effects on integrity of neurons by detoxification routes, anti-inflammatory effects and neurotropic synthesis, also associated with reduced β-amyloid plaques, a hallmark of Alzheimer’s disease. In older adults, the integrity of the skin decreases with aging. Skin thinning and transdermal cholesterol decreases the efficiency of UVB vitamin D production by up to 50% compared to younger adults. Lower levels of vitamin D were repeatedly found to be associated with worse memory performance, executive dysfunction and overall impaired cognitive functioning in older adults. The risk of cognitive impairment was up to 4 times greater in the severely deficient elders ([25(OH)D] <25nmol/L) in comparison with individuals with adequate levels (>75nmol/L). Even if vitamin D levels of patients with severe vitamin D deficiency were increased to an adequate level, the cognitive performance of patients did not reach to the cognitive performance of patients whose vitamin D levels were adequate from the beginning. |
| Keywords: | Key words: Vitamin D deficiency, Cognitive function , Older adults, Dementia, 25-hydroxyvitamin D. |
| Cite Article: | "Low levels of vitamin D linked to poor cognitive function in older adults ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 1, page no.c131-c136, January-2023, Available :http://www.ijnrd.org/papers/IJNRD2301217.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2301217 Registration ID: 186213 Published In: Volume 8 Issue 1, January-2023 DOI (Digital Object Identifier): Page No: c131-c136 Country: Narasaraopet, Guntur, Andhra Pradesh, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2301217 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2301217 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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