Paper Title
Immuno-oncology agents for cancer therapy
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Registration ID: IJNRD_186177
Published ID: IJNRD2301198
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Immuno-oncology agents for cancer therapy
Abstract
Until recently, cancer therapy comprised of four main types of treatment: surgery, radiotherapy, chemotherapy, and targeted therapy. Over the past decade, immuno-oncology (IO) has emerged as a novel and important approach to cancer treatment through the stimulation of the body’s own immune system to kill cancer cells. This newly recognised method of treating cancer is rapidly developing, with many accelerated approvals by the US Food and Drug Administration and European Medicines Agency in 2019.[8] Several therapeutic classes have emerged within IO and are the focus of this review article. In particular, the immune checkpoint inhibitors have had remarkable success across multiple malignancies and are the most well- established therapeutic class of IO agents to date. Biomarker testing for the programmed death-ligand 1 (PD-L1) checkpoint target has been developed and is now obligatory before treatment with pembrolizumab (Keytruda, Merck) when used for non-small-cell lung carcinoma, gastric cancer, head and neck squamous cell carcinoma and cervical cancer, as well as before treatment with atezolizumab (Tecentriq, Roche) when used for urothelial carcinoma. However, ambiguity remains as to the relevance of PD-L1 expression for checkpoint inhibition therapy for other tumour types. More recently, combining IO agents with conventional therapies has been evaluated with some significant improvements in patient outcomes.
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How To Cite (APA)
Shubham .S .Sanap , SUMEDH S. SHIVGAN, Yogita M.Vispute , Ashwini R.Bharati, & puja G.Vyawhare (January-2023). Immuno-oncology agents for cancer therapy. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(1), b795-b809. https://ijnrd.org/papers/IJNRD2301198.pdf
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Volume 8 Issue 1, January-2023
Pages : b795-b809
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Paper Reg. ID: IJNRD_186177
Published Paper Id: IJNRD2301198
Research Area: Engineering
Author Type: Foreign Author
Country: -, -, -
Published Paper PDF: https://ijnrd.org/papers/IJNRD2301198.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2301198
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