DEVELOPMENT AND CHARACTERIZATION OF SILVER NANOPARTICLE OF stevia rebaudiana BERT EXTRACT FOR HEPATOPROTECTIVE ACTIVITY IN PARACETAMOL INDUCE TOXICITY

DEVELOPMENT AND CHARACTERIZATION OF SILVER NANOPARTICLE OF stevia rebaudiana BERT EXTRACT FOR HEPATOPROTECTIVE ACTIVITY IN PARACETAMOL INDUCE TOXICITY

Registration ID: IJNRD_185426

Published ID: IJNRD2212317

DOI: Click Here to Get

Gajendra Singh Thakur , Pushpendra Ahirwar , Raghuraj Singh , Umesh K. Patil

Natural extract, silver nanoparticles, Anti hepatoprotective activity, Stevia rabaudiana

Stevia rebaudiana Bert is a medicinal plant that is widely used in traditional medicine owing to its broad range of therapeutic activities. Despite its promising pharmacological activities, using plant extracts has several limitations that can be overcome using pharmaceutical nanotechnology. The aim of this study was to systematically investigate the effect of silver nanoparticles (Ag-NPs) on the hepatoprotective activities of stevia rebaudiana B. extract. Silver nanoparticles (Ag-NPs) were prepared using the green synthesis method and characterized in terms of size, polydispersity index, zeta potential, encapsulation efficiency, high-performance thin layer chromatography (HPTLC), X-ray diffraction, differential scanning calorimetry, and release profile. Transmission electron microscopy was used to observe the morphology of the nanoparticles. The mean particle size, zeta potential, and encapsulation efficiency of optimized NA-CSNPs were 137.5 nm, 0.226, -33.76 mV, and 50.12%, respectively. The release profile of the Ag-NPs was mainly dependent on the pH of the surrounding medium, and the Stevia rebaudiana B. extract was released in a controlled manner over time. However, hepatic stellate cells, hepatocytes, and It cells are directly and indirectly affected during hepatotoxicity. Their over-activation revealed another approach to liver injury due to the influence of any toxicant. Taken together, the results of this study highlighted the advantages of using NPS as a nanocarrier for herbal extracts, thus providing a potential strategy for improving plant-based therapeutics.

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"DEVELOPMENT AND CHARACTERIZATION OF SILVER NANOPARTICLE OF stevia rebaudiana BERT EXTRACT FOR HEPATOPROTECTIVE ACTIVITY IN PARACETAMOL INDUCE TOXICITY", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 12, page no.d153-d172, December-2022, Available :https://ijnrd.org/papers/IJNRD2212317.pdf

Volume 7 Issue 12, December-2022

Pages : d153-d172

Paper Reg. ID: IJNRD_185426

Published Paper Id: IJNRD2212317

Downloads: 000121160

Research Area: Medical Science

Country: Sagar, Madhyapradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2212317.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212317

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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