Paper Title
DEVELOPMENT AND CHARACTERIZATION OF SILVER NANOPARTICLE OF stevia rebaudiana BERT EXTRACT FOR HEPATOPROTECTIVE ACTIVITY IN PARACETAMOL INDUCE TOXICITY
Article Identifiers
Authors
Gajendra Singh Thakur , Pushpendra Ahirwar , Raghuraj Singh , Umesh K. Patil
Keywords
Natural extract, silver nanoparticles, Anti hepatoprotective activity, Stevia rabaudiana
Abstract
Stevia rebaudiana Bert is a medicinal plant that is widely used in traditional medicine owing to its broad range of therapeutic activities. Despite its promising pharmacological activities, using plant extracts has several limitations that can be overcome using pharmaceutical nanotechnology. The aim of this study was to systematically investigate the effect of silver nanoparticles (Ag-NPs) on the hepatoprotective activities of stevia rebaudiana B. extract. Silver nanoparticles (Ag-NPs) were prepared using the green synthesis method and characterized in terms of size, polydispersity index, zeta potential, encapsulation efficiency, high-performance thin layer chromatography (HPTLC), X-ray diffraction, differential scanning calorimetry, and release profile. Transmission electron microscopy was used to observe the morphology of the nanoparticles. The mean particle size, zeta potential, and encapsulation efficiency of optimized NA-CSNPs were 137.5 nm, 0.226, -33.76 mV, and 50.12%, respectively. The release profile of the Ag-NPs was mainly dependent on the pH of the surrounding medium, and the Stevia rebaudiana B. extract was released in a controlled manner over time. However, hepatic stellate cells, hepatocytes, and It cells are directly and indirectly affected during hepatotoxicity. Their over-activation revealed another approach to liver injury due to the influence of any toxicant. Taken together, the results of this study highlighted the advantages of using NPS as a nanocarrier for herbal extracts, thus providing a potential strategy for improving plant-based therapeutics.
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How To Cite (APA)
Gajendra Singh Thakur, Pushpendra Ahirwar, Raghuraj Singh, & Umesh K. Patil (December-2022). DEVELOPMENT AND CHARACTERIZATION OF SILVER NANOPARTICLE OF stevia rebaudiana BERT EXTRACT FOR HEPATOPROTECTIVE ACTIVITY IN PARACETAMOL INDUCE TOXICITY. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), d153-d172. https://ijnrd.org/papers/IJNRD2212317.pdf
Issue
Volume 7 Issue 12, December-2022
Pages : d153-d172
Other Publication Details
Paper Reg. ID: IJNRD_185426
Published Paper Id: IJNRD2212317
Downloads: 000121980
Research Area: Medical Science
Country: Sagar, Madhyapradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2212317.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212317
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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