Paper Title
FORMULATION AND EVALUATION OF NANOPARTICLES OF NYCTANTHES ARBORTRISTIS LINN. SEED EXTRACT FOR HEPATOPROTECTIVE ACTIVITY
Article Identifiers
: Keywords
Natural extract, chitosan nanoparticles, Anti hepatoprotective activity, Nyctanthes arbortristis
Abstract
Nyctanthes arbortristis Linn (NA) is a medicinal plant that is widely used in traditional medicine owing to its broad range of therapeutic activities. Despite its promising pharmacological activities, the use of plant extracts has several limitations which can be overcome using pharmaceutical nanotechnology. The aim of this study was to systematically investigate the effect of nanoparticles on the hepatoprotective activities of NA extract. NA-loaded chitosan nanoparticles (NA-CSNPs) were prepared using the ionic gelation method and characterized in terms of size, polydispersity index, zeta potential, encapsulation efficiency, and release profile. Transmission electron microscopy was used to observe the morphology of the nanoparticles. The mean particle size, zeta potential, and encapsulation efficiency of optimized NA-CSNPs were 187.2 nm, -2.15 mV, and 69.12%, respectively. The release profile of the NA-CSNPs was mainly dependent on the pH of the surrounding medium, and the NA extract was released in a controlled manner over time. free radicals, inflammatory marker genetic disability, etc., which leads to various pathological changes. However, hepatic stellate cells, hepatocytes, and It cells are directly and indirectly affected during hepatotoxicity. Their over-activation revealed another approach to liver injury due to the influence of any toxicant. Computational analysis results supported the in vitro finding that NA-CSNPs act as antihepatoprotective agents. Taken together, the results of this study highlighted the advantages of using CSNPs as a nanocarrier for herbal extracts, thus providing a potential strategy for improving plant-based therapeutics.
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How To Cite (APA)
Pushpendra Ahirwar, Devyani Rajput, Mandeep Singh, Gajendra Singh Thakur, & Umesh K. Patil (December-2022). FORMULATION AND EVALUATION OF NANOPARTICLES OF NYCTANTHES ARBORTRISTIS LINN. SEED EXTRACT FOR HEPATOPROTECTIVE ACTIVITY. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), c926-c939. https://ijnrd.org/papers/IJNRD2212289.pdf
Issue
Volume 7 Issue 12, December-2022
Pages : c926-c939
Other Publication Details
Paper Reg. ID: IJNRD_185332
Published Paper Id: IJNRD2212289
Downloads: 000122002
Research Area: Pharmacy
Author Type: Indian Author
Country: sagar, Madya pradesh , india
Published Paper PDF: https://ijnrd.org/papers/IJNRD2212289.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212289
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