FORMULATION AND EVALUATION OF NANOPARTICLES OF NYCTANTHES ARBORTRISTIS LINN. SEED EXTRACT FOR HEPATOPROTECTIVE ACTIVITY

FORMULATION AND EVALUATION OF NANOPARTICLES OF NYCTANTHES ARBORTRISTIS LINN. SEED EXTRACT FOR HEPATOPROTECTIVE ACTIVITY

Registration ID: IJNRD_185332

Published ID: IJNRD2212289

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Pushpendra Ahirwar , Devyani Rajput , Mandeep Singh , Gajendra Singh Thakur , Umesh K. Patil

Natural extract, chitosan nanoparticles, Anti hepatoprotective activity, Nyctanthes arbortristis

Nyctanthes arbortristis Linn (NA) is a medicinal plant that is widely used in traditional medicine owing to its broad range of therapeutic activities. Despite its promising pharmacological activities, the use of plant extracts has several limitations which can be overcome using pharmaceutical nanotechnology. The aim of this study was to systematically investigate the effect of nanoparticles on the hepatoprotective activities of NA extract. NA-loaded chitosan nanoparticles (NA-CSNPs) were prepared using the ionic gelation method and characterized in terms of size, polydispersity index, zeta potential, encapsulation efficiency, and release profile. Transmission electron microscopy was used to observe the morphology of the nanoparticles. The mean particle size, zeta potential, and encapsulation efficiency of optimized NA-CSNPs were 187.2 nm, -2.15 mV, and 69.12%, respectively. The release profile of the NA-CSNPs was mainly dependent on the pH of the surrounding medium, and the NA extract was released in a controlled manner over time. free radicals, inflammatory marker genetic disability, etc., which leads to various pathological changes. However, hepatic stellate cells, hepatocytes, and It cells are directly and indirectly affected during hepatotoxicity. Their over-activation revealed another approach to liver injury due to the influence of any toxicant. Computational analysis results supported the in vitro finding that NA-CSNPs act as antihepatoprotective agents. Taken together, the results of this study highlighted the advantages of using CSNPs as a nanocarrier for herbal extracts, thus providing a potential strategy for improving plant-based therapeutics.

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"FORMULATION AND EVALUATION OF NANOPARTICLES OF NYCTANTHES ARBORTRISTIS LINN. SEED EXTRACT FOR HEPATOPROTECTIVE ACTIVITY", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 12, page no.c926-c939, December-2022, Available :https://ijnrd.org/papers/IJNRD2212289.pdf

Volume 7 Issue 12, December-2022

Pages : c926-c939

Paper Reg. ID: IJNRD_185332

Published Paper Id: IJNRD2212289

Downloads: 000121200

Research Area: Pharmacy

Country: sagar, Madya pradesh , india

Published Paper PDF: https://ijnrd.org/papers/IJNRD2212289.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212289

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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