Evaluation of Antidepressant Effect of 6-Shogaol in animal models

Registration ID: IJNRD_185082

Published ID: IJNRD2212225

DOI: Click Here to Get

shalinee soni , meraj khan , ritika soni

Keywords Shogaol, extract, tail suspension, forced swim, antidepressant, isolation

Abstract The objective of the study was therefore to evaluate the role of 6-shogaol in the antidepressant effect Zingiber officinale using two different animal models viz., tail suspension test and forced swim test. Ginger rhizomes were extracted using water-methanol (80/20) as the solvent using maceration and 6-shogaol was isolated from the extract using mixture of n-hexane-diethyl ether (70/30, v/v) in column chromatography. The yield of the isolated 6-shogaol after column chromatographic isolation of the aqueous methanolic ginger extract was found to be 1.3%. The isolated 6-shogaol was of pale-yellow color and the texture appeared to be fine and crystalline. The forced swim test revealed that the immobility time was significantly reduced at all the administered doses of 6-shogaol in a dose dependent manner. The swimming time was found to increase in a similar fashion but was not significantly increased at a dose of 30 mg/kg of 6-shogaol. ANOVA analysis of the tail suspension test revealed that the reduction of immobility time was not significant at a dose of 30 mg/kg 6-shogoal whereas at doses of 100 and 300 mg/kg, the reduction was significant as compared to the control group.

Published Paper   E-Certificate

shalinee soni , meraj khan, & ritika soni (December-2022). Evaluation of Antidepressant Effect of 6-Shogaol in animal models. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), c204-c212. https://ijnrd.org/papers/IJNRD2212225.pdf

Volume 7 Issue 12, December-2022

Pages : c204-c212

Paper Reg. ID: IJNRD_185082

Published Paper Id: IJNRD2212225

Downloads: 000121981

Research Area: Pharmacy

Country: bhopal, madhya pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2212225.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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