Paper Title
DESIGN DEVELOPMENT AND FORMULATION OF CONTROLLED RELEASED MICROSPHERE OF ANTI-DIABETIC DRUG
Article Identifiers
Authors
Mr. Ajit Das , Dr. C.K. Tyagi
Keywords
DESIGN DEVELOPMENT AND FORMULATION OF CONTROLLED RELEASED MICROSPHERE OF ANTI-DIABETIC DRUG
Abstract
The objective of the present study was to develop Gliclazide microspheres in order to achieve an extended retention in the upper GIT. Which may result in enhance the absorption and improve the bioavailability. The microspheres were prepared by emulsion solvent diffusion-evaporation method using different ratios of rate controlling polymer poloxamer 407, Gliclazide is used in each formulation at constant ratio. The mixture of dichloromethane and ethanol at ratio of (1:1), with tween 80 as the surfactant. The prepared microspheres were evaluated for percentage yield, particle size, entrapment efficiency, shape and surface characterization, in vitro dissolution studies and drug release mechanism was interpretated by kinetic model. The effect of polymer concentration on these parameters was investigated. The studies revealed that increase in concentration of hydrophilic non-ionic polymer (Poloxamer 407) increased the drug release from the microspheres. The formulation F6 (Gliclazide: poloxamer 407 is 1:6) was selected as best formulation, and it follows zero order drug release with 89.36% entrapment efficiency, 98.16% drug content, 93.85% In-vitro drug release at 12thhour.
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How To Cite (APA)
Mr. Ajit Das & Dr. C.K. Tyagi (December-2022). DESIGN DEVELOPMENT AND FORMULATION OF CONTROLLED RELEASED MICROSPHERE OF ANTI-DIABETIC DRUG. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), b727-b739. https://ijnrd.org/papers/IJNRD2212183.pdf
Issue
Volume 7 Issue 12, December-2022
Pages : b727-b739
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Paper Reg. ID: IJNRD_185027
Published Paper Id: IJNRD2212183
Downloads: 000121985
Research Area: Engineering
Country: -, -, -
Published Paper PDF: https://ijnrd.org/papers/IJNRD2212183.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212183
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