Modified Silicon Nanowire Biosensor:Synthesis Method and Early Cancer Diagnosis

Modified Silicon Nanowire Biosensor:Synthesis Method and Early Cancer Diagnosis

Registration ID: IJNRD_184565

Published ID: IJNRD2212170

DOI: Click Here to Get

Inamdar Farheen Muzammil , Kongale Aishwarya Bankat

Silicon nanowire, Biosensor, Surface functionalization , Electron lithography, 8-hydroxydeoxyguanosine(8-OHdG), electronic readout, cancer biomarkers, gold nanoparticles, quantum dots, carbon nanotubes, nanowires, micro consoles

In this paper, we present ultrasensitive silicon nanowire (SiNW)-based biosensor devices fordetection of disease biomarkers. The electrochemically induced functionalization method has was used to transplant antibodies targeted against a prostate cancer risk biomarker 8- of hydroxydeoxyguanosine (8-OHdG) onto SiNW surfaces. Antibody functionalized SiNWsensor was used to detect the binding of the biomarker 8-OHdG to the SiNW surface inside seconds of exposure. Detection of 8-OHdG concentrations as low as 1 ng/ml (3.5 nM) was proven. The active device has been connected to a disposable printed circuit board that can be inserted into the electronic reading system as part of an integrated Point of Care (POC) diagnostic. The speed, sensitivity, and ease of biomarker detection using SiNW sensors are depicted they are ideal for eventual POC diagnostics. A huge amount of research and development has been done in the field of nanotechnology and many nanomaterials have been used to detect cancer in its early stages. Nanomaterials have unique physical, optical and electrical properties that have been proven very useful for scanning. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon over the years, nanotubes, gold nanowires, and many other materials have been developed, along with the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. The basis is proteins, antibody fragments, DNA fragments and RNA fragments cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future we might be able to detect cancer very early stage, providing a much higher chance of treatment.

Published Paper   E-Certificate

"Modified Silicon Nanowire Biosensor:Synthesis Method and Early Cancer Diagnosis ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 12, page no.b590-b604, December-2022, Available :https://ijnrd.org/papers/IJNRD2212170.pdf

Volume 7 Issue 12, December-2022

Pages : b590-b604

Paper Reg. ID: IJNRD_184565

Published Paper Id: IJNRD2212170

Downloads: 000121127

Research Area: Pharmacy

Country: Latur , Maharashtra , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2212170.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212170

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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