Paper Title
Modified Silicon Nanowire Biosensor:Synthesis Method and Early Cancer Diagnosis
Article Identifiers
: Keywords
Silicon nanowire, Biosensor, Surface functionalization , Electron lithography, 8-hydroxydeoxyguanosine(8-OHdG), electronic readout, cancer biomarkers, gold nanoparticles, quantum dots, carbon nanotubes, nanowires, micro consoles
Abstract
In this paper, we present ultrasensitive silicon nanowire (SiNW)-based biosensor devices fordetection of disease biomarkers. The electrochemically induced functionalization method has was used to transplant antibodies targeted against a prostate cancer risk biomarker 8- of hydroxydeoxyguanosine (8-OHdG) onto SiNW surfaces. Antibody functionalized SiNWsensor was used to detect the binding of the biomarker 8-OHdG to the SiNW surface inside seconds of exposure. Detection of 8-OHdG concentrations as low as 1 ng/ml (3.5 nM) was proven. The active device has been connected to a disposable printed circuit board that can be inserted into the electronic reading system as part of an integrated Point of Care (POC) diagnostic. The speed, sensitivity, and ease of biomarker detection using SiNW sensors are depicted they are ideal for eventual POC diagnostics. A huge amount of research and development has been done in the field of nanotechnology and many nanomaterials have been used to detect cancer in its early stages. Nanomaterials have unique physical, optical and electrical properties that have been proven very useful for scanning. Quantum dots, gold nanoparticles, magnetic nanoparticles, carbon over the years, nanotubes, gold nanowires, and many other materials have been developed, along with the discovery of a wide range of biomarkers to lower the detection limit of cancer biomarkers. The basis is proteins, antibody fragments, DNA fragments and RNA fragments cancer biomarkers and have been used as targets in cancer detection and monitoring. It is highly anticipated that in the near future we might be able to detect cancer very early stage, providing a much higher chance of treatment.
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How To Cite (APA)
Inamdar Farheen Muzammil & Kongale Aishwarya Bankat (December-2022). Modified Silicon Nanowire Biosensor:Synthesis Method and Early Cancer Diagnosis . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), b590-b604. https://ijnrd.org/papers/IJNRD2212170.pdf
Issue
Volume 7 Issue 12, December-2022
Pages : b590-b604
Other Publication Details
Paper Reg. ID: IJNRD_184565
Published Paper Id: IJNRD2212170
Downloads: 000122256
Research Area: Pharmacy
Author Type: Indian Author
Country: Latur , Maharashtra , India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2212170.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212170
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