FORMULATION AND EVALUATION OF FLOATING BILAYER TABLET OF METFORMIN HYDROCHLORIDE AND CHLORPROPAMIDE

Registration ID: IJNRD_184991

Published ID: IJNRD2212158

DOI: Click Here to Get

Mr. Ravi , Mr. Firoz Khan , Ms. Sana Sahil , Ms. Nida Khan , Dr. C.K. Tyagi

Diabetes, Chlorpropamide, Metformin HCL, Bilayer tablet

The present investigation studied a novel bilayer tablet having an extended release system. There has been 70 years of research and development experience in the sustained drug release area since the patent, and a number of strategies have been developed to prolong drug level in the body. With many drugs, the basic goal of therapy is to achieve a steady-state blood or tissue level that therapeutically effective and non-toxic for an extended period of time. Floating Bilayer tablet of Metformin HCl as Instant Layer and Chlorpropamide as control layer were formulated using, HPMC, Sodium carboxymethyl cellulose, Microcrystalline cellulose, Sodium starch glycolate, Magnesium stearate in combination of different percentage of polymer. Nine different formulations of floating Chlorpropamide SR tablets are prepared by employing the hydrophilic polymer HPMC in different viscosity grades in the percentage. From this study it was concluded that Floating time increases, it decreases the release rate. So it suitable for sustained release formulation. The two agents were found to have a remarkable effect on glycemic control. In the present investigation a bilayer tablet was prepared in which one layer gives instant action against diabetes and another layer maintain concentration of drug in plasma for longer periods.

Published Paper   E-Certificate

Mr. Ravi, Mr. Firoz Khan, Ms. Sana Sahil, Ms. Nida Khan, & Dr. C.K. Tyagi (December-2022). FORMULATION AND EVALUATION OF FLOATING BILAYER TABLET OF METFORMIN HYDROCHLORIDE AND CHLORPROPAMIDE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), b518-b529. https://ijnrd.org/papers/IJNRD2212158.pdf

Volume 7 Issue 12, December-2022

Pages : b518-b529

Paper Reg. ID: IJNRD_184991

Published Paper Id: IJNRD2212158

Downloads: 000121979

Research Area: Engineering

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Published Paper PDF: https://ijnrd.org/papers/IJNRD2212158.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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