ALGILINE DIFERULOYLMETHANE NONSUBMERSIBLE CHAPLET CONTAINING DIFERULOYLMETHANE ROCK-HARD DISSEMINATION: PREPARATION AND EVALUATION OF STABILITY, SOLUBILITY AND BIOAVAILABILITY.

Registration ID: IJNRD_184799

Published ID: IJNRD2212120

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JITENDRA DEVCHAND MORE , SHAILESH B. PATIL , CHHAYA GADGOLI , C. P. SURYAWANSHI , AMIT SINHAL

Diferuloylmethane, Rock hard dissemination, Algiline, Diferuloylmethane Nonsubmersible chaplet, Bioavailability, Gelucire@44/14.

Diferuloylmethane is a major component of rhizomes of Curcuma longa and has array of pharmacological activities. Poor bioavailability of the molecule is due to its poor solubility in water. In the present study, an attempt is made to increase the water solubility through preparation of Rock Hard Dissemination (RHD) of Diferuloylmethane and Gelucire®44/14, followed by incorporation of the same in Algiline Nonsubmersible Chaplet (ANSC). The formation of RHD was confirmed through FT-IR and DSC –TG analysis. The maximum entrapment of Diferuloylmethane in the chaplet was found to be 30 % w/w. The dissolution studies of the chaplet in 0.1N HCl, revealed that the Diferuloylmethane release from the chaplet containing RHD is significantly (p<0.001) higher than the chaplet containing plain Diferuloylmethane. Pharmacokinetic studies on chaplet containing RHD of Diferuloylmethane indicated significantly (P< 0.001) higher levels of Diferuloylmethane serum as compared to the plain Diferuloylmethane.

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JITENDRA DEVCHAND MORE, SHAILESH B. PATIL, CHHAYA GADGOLI, C. P. SURYAWANSHI, & AMIT SINHAL (December-2022). ALGILINE DIFERULOYLMETHANE NONSUBMERSIBLE CHAPLET CONTAINING DIFERULOYLMETHANE ROCK-HARD DISSEMINATION: PREPARATION AND EVALUATION OF STABILITY, SOLUBILITY AND BIOAVAILABILITY.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), b209-b222. https://ijnrd.org/papers/IJNRD2212120.pdf

Volume 7 Issue 12, December-2022

Pages : b209-b222

Paper Reg. ID: IJNRD_184799

Published Paper Id: IJNRD2212120

Downloads: 000121979

Research Area: Pharmacy

Country: DHULE, MAHARASHTRA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2212120.pdf

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