ALGILINE DIFERULOYLMETHANE NONSUBMERSIBLE CHAPLET CONTAINING DIFERULOYLMETHANE ROCK-HARD DISSEMINATION: PREPARATION AND EVALUATION OF STABILITY, SOLUBILITY AND BIOAVAILABILITY.

ALGILINE DIFERULOYLMETHANE NONSUBMERSIBLE CHAPLET CONTAINING DIFERULOYLMETHANE ROCK-HARD DISSEMINATION: PREPARATION AND EVALUATION OF STABILITY, SOLUBILITY AND BIOAVAILABILITY.

Registration ID: IJNRD_184799

Published ID: IJNRD2212120

DOI: Click Here to Get

JITENDRA DEVCHAND MORE , SHAILESH B. PATIL , CHHAYA GADGOLI , C. P. SURYAWANSHI , AMIT SINHAL

Diferuloylmethane, Rock hard dissemination, Algiline, Diferuloylmethane Nonsubmersible chaplet, Bioavailability, Gelucire@44/14.

Diferuloylmethane is a major component of rhizomes of Curcuma longa and has array of pharmacological activities. Poor bioavailability of the molecule is due to its poor solubility in water. In the present study, an attempt is made to increase the water solubility through preparation of Rock Hard Dissemination (RHD) of Diferuloylmethane and Gelucire®44/14, followed by incorporation of the same in Algiline Nonsubmersible Chaplet (ANSC). The formation of RHD was confirmed through FT-IR and DSC –TG analysis. The maximum entrapment of Diferuloylmethane in the chaplet was found to be 30 % w/w. The dissolution studies of the chaplet in 0.1N HCl, revealed that the Diferuloylmethane release from the chaplet containing RHD is significantly (p<0.001) higher than the chaplet containing plain Diferuloylmethane. Pharmacokinetic studies on chaplet containing RHD of Diferuloylmethane indicated significantly (P< 0.001) higher levels of Diferuloylmethane serum as compared to the plain Diferuloylmethane.

Published Paper   E-Certificate

"ALGILINE DIFERULOYLMETHANE NONSUBMERSIBLE CHAPLET CONTAINING DIFERULOYLMETHANE ROCK-HARD DISSEMINATION: PREPARATION AND EVALUATION OF STABILITY, SOLUBILITY AND BIOAVAILABILITY.", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 12, page no.b209-b222, December-2022, Available :https://ijnrd.org/papers/IJNRD2212120.pdf

Volume 7 Issue 12, December-2022

Pages : b209-b222

Paper Reg. ID: IJNRD_184799

Published Paper Id: IJNRD2212120

Downloads: 000121132

Research Area: Pharmacy

Country: DHULE, MAHARASHTRA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2212120.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212120

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

IJNRD is Scholarly open access journals, Peer-reviewed, and Refereed Journals, High Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool), Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) with Open-Access Publications.

INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

Indexing In Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar | AI-Powered Research Tool, Microsoft Academic, Academia.edu, arXiv.org, Research Gate, CiteSeerX, ResearcherID Thomson Reuters, Mendeley : reference manager, DocStoc, ISSUU, Scribd, and many more

How to submit the paper?

Important Dates for Current issue

Paper Submission Open For: August 2025

Current Issue: Volume 10 | Issue 8

Last Date for Paper Submission: Till 31-Aug-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: International Peer-reviewed, Refereed, and Open Access Journal.

Subject Category: Research Area