TO DEVELOP AN ALTERNATE EFFICIENT MICROPARTICULATE SYSTEM(S) FOR ANTITUBERCULAR DRUG(S) BY ENGINEERING THE SURFACE OF PARTICLES TO REACH MYCOBACTERIUM INTRACELLULARLY

Registration ID: IJNRD_184687

Published ID: IJNRD2212085

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Kanchan Galgate

Rifampicin, Chitosan, antitubercular drug, In-vivo study

Due to its status as the biggest infectious disease killer globally, along with HIV infection, tuberculosis (TB) continues to be a serious global health concern (HIV). A important opportunistic illness among people with a high incidence of AIDS is tuberculosis (TB). Mycobacterium tuberculosis (MTB), which causes TB, is a lethal infectious illness that primarily affects the respiratory system. Meningitis, circulatory tuberculosis, lymphatic tuberculosis, genitourinary tuberculosis, bones, and joints are other major public health concerns caused by MTB. Pharmacokinetic event showed that an experimental carrier's drug plasma profile is significantly influenced by the physico-chemical properties of the polymer. Tmax for RIF (Free) was found to be 2.890.31hr, whereas Tmax for the chitosan ascorbate formulation was found to be 13.250.01hr and 16.410.81hr for C3S3P4T2R and C3S3P4T2I, respectively. The results make it abundantly apparent that MMAD did not significantly change when the formulations were kept in a refrigerator. Although the MMAD significantly varied when the formulations were held at room temperature, it nevertheless stayed within the range of respirable particles that alveolar macrophages can effectively absorb. The amount of drug that has been incorporated into the formulation determines its therapeutic impact; as a result, the residual drug content was tracked and contrasted with the results from the stability testing phase. The results suggested that the conjugation with ligand greatly decreased the leaching of medication from formulations. This finding may be related to the bulky group on the surface of microspheres, which may have prevented some drug leakage.

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Kanchan Galgate (December-2022). TO DEVELOP AN ALTERNATE EFFICIENT MICROPARTICULATE SYSTEM(S) FOR ANTITUBERCULAR DRUG(S) BY ENGINEERING THE SURFACE OF PARTICLES TO REACH MYCOBACTERIUM INTRACELLULARLY. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), a625-a641. https://ijnrd.org/papers/IJNRD2212085.pdf

Volume 7 Issue 12, December-2022

Pages : a625-a641

Paper Reg. ID: IJNRD_184687

Published Paper Id: IJNRD2212085

Research Area: Pharmacy

Author Type: Indian Author

Country: Ahmednagar, maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2212085.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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