Paper Title
TO DEVELOP AN ALTERNATE EFFICIENT MICROPARTICULATE SYSTEM(S) FOR ANTITUBERCULAR DRUG(S) BY ENGINEERING THE SURFACE OF PARTICLES TO REACH MYCOBACTERIUM INTRACELLULARLY
Article Identifiers
Authors
Kanchan Galgate
Keywords
Rifampicin, Chitosan, antitubercular drug, In-vivo study
Abstract
Due to its status as the biggest infectious disease killer globally, along with HIV infection, tuberculosis (TB) continues to be a serious global health concern (HIV). A important opportunistic illness among people with a high incidence of AIDS is tuberculosis (TB). Mycobacterium tuberculosis (MTB), which causes TB, is a lethal infectious illness that primarily affects the respiratory system. Meningitis, circulatory tuberculosis, lymphatic tuberculosis, genitourinary tuberculosis, bones, and joints are other major public health concerns caused by MTB. Pharmacokinetic event showed that an experimental carrier's drug plasma profile is significantly influenced by the physico-chemical properties of the polymer. Tmax for RIF (Free) was found to be 2.890.31hr, whereas Tmax for the chitosan ascorbate formulation was found to be 13.250.01hr and 16.410.81hr for C3S3P4T2R and C3S3P4T2I, respectively. The results make it abundantly apparent that MMAD did not significantly change when the formulations were kept in a refrigerator. Although the MMAD significantly varied when the formulations were held at room temperature, it nevertheless stayed within the range of respirable particles that alveolar macrophages can effectively absorb. The amount of drug that has been incorporated into the formulation determines its therapeutic impact; as a result, the residual drug content was tracked and contrasted with the results from the stability testing phase. The results suggested that the conjugation with ligand greatly decreased the leaching of medication from formulations. This finding may be related to the bulky group on the surface of microspheres, which may have prevented some drug leakage.
Downloads
How To Cite (APA)
Kanchan Galgate (December-2022). TO DEVELOP AN ALTERNATE EFFICIENT MICROPARTICULATE SYSTEM(S) FOR ANTITUBERCULAR DRUG(S) BY ENGINEERING THE SURFACE OF PARTICLES TO REACH MYCOBACTERIUM INTRACELLULARLY. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(12), a625-a641. https://ijnrd.org/papers/IJNRD2212085.pdf
Issue
Volume 7 Issue 12, December-2022
Pages : a625-a641
Other Publication Details
Paper Reg. ID: IJNRD_184687
Published Paper Id: IJNRD2212085
Downloads: 000121975
Research Area: Pharmacy
Country: Ahmednagar, maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2212085.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2212085
About Publisher
Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG
Licence
This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
Publication Timeline
Article Preview: View Full Paper
Call For Paper
IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.
The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.
Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.
How to submit the paper?
By Our website
Click Here to Submit Paper Online
Important Dates for Current issue
Paper Submission Open For: October 2025
Current Issue: Volume 10 | Issue 10 | October 2025
Impact Factor: 8.76
Last Date for Paper Submission: Till 31-Oct-2025
Notification of Review Result: Within 1-2 Days after Submitting paper.
Publication of Paper: Within 01-02 Days after Submititng documents.
Frequency: Monthly (12 issue Annually).
Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.
Subject Category: Research Area
Call for Paper: More Details
