Rationalizing Biological Pathways Responsible In Metastatic Triple Negative Breast Cancer via Identification and Validation of Hub Genes

Registration ID: IJNRD_184386

Published ID: IJNRD2211266

DOI: http://doi.one/10.1729/Journal.32288

Architha Sankar

Hub Genes, Triple-Negative Breast Cancer, In-silico Analysis, DEG’s, Metastasis.

Triple Negative Breast Cancer (TNBC) is a severe form of breast cancer with an increased incidence of metastasis and relapse. Since, the current conventional method of treatment remains ineffective due to poor diagnosis and lack of therapeutic targets, it remains an unsettling challenge for both researchers and clinicians in the field. The centerpiece of our study was to unwind the Differentially Expressed Genes (DEGs), its pathway enrichment analysis underlying the metastatic condition of the disease. We had chosen multiple datasets from distant metastasis and metastatic TNBC stages for investigation. From these disease-specific expression network analysis, ten hub genes namely: SMC4, BUB1B, CCNA2, KIF2C, KIF15, PBK, CDCA5, CENPE, ZWINT and MELK were identified and validated by survival and correlation analysis. In our attempt to highlight the biological pathway that our hub genes were majorly involved, further analysis revealed that cleavage of centromeric cohesion by ESPL1 (Separase) in mitotic cell cycle were found to be enriched which demonstrates that these hub genes are responsible in triggering tumor invasion and metastasis. Concisely, our report will aid in gaining a better understanding of biological complexities, revealing potential biomarkers and therapeutic targets implicated in metastasis of TNBC.

Published Paper   E-Certificate

Architha Sankar (November-2022). Rationalizing Biological Pathways Responsible In Metastatic Triple Negative Breast Cancer via Identification and Validation of Hub Genes. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(11), c543-c554. http://doi.one/10.1729/Journal.32288

Volume 7 Issue 11, November-2022

Pages : c543-c554

Paper Reg. ID: IJNRD_184386

Published Paper Id: IJNRD2211266

Downloads: 000121994

Research Area: Biological Science

Country: Chennai, Tamil Nadu, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2211266.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2211266

Crossref DOI: http://doi.one/10.1729/Journal.32288

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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