Aimovig serving as a miracle drug for chronic migraine – A clinical Review

Registration ID: IJNRD_184214

Published ID: IJNRD2211257

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MARY MANISHA MANNAM, Dr. Sneha Thakur, Uma Rani Yadagiri

Aimovig, calcitonin gene related peptide receptor, headache, Migraine.

Migraine being a very serious issue unaddressed by most of the patient assuming it as a normal headache is leading to the chronic conditions of the individual. These conditions are increasing across the globe and the awareness within our communities need to be taken care of as it is a complex neurological disorder which is related to several CNS systems such as sensorics and motoric, cognitive, affective and autonomous systems is categorised as migraine. The calcitonin gene related peptide receptor (CGRP) is the receptor of calcitonin family which also includes amylin, adrenomedullin and calcitonin receptors. Among these CGRP receptors play a major role in migraine but its exact role is yet to be analysed. Already existing treatments such as Triptans showed high agonist activity at serotonin receptors but not every triptan has the affinity at the receptors. However, Patients mentioned that the response of the body towards this triptans is poor and others may have headache recurrence and chest syndromes. Aimovig a miracle drug came to existence showing its effectiveness more appropriately and significantly by pre-clinical and clinical studies proving to show the statistical analysis of 70mg of aimovig shows p value of <0.001 and of 140mg p value of <0.001 which are similar. The secondary outcomes of the results are the % of participants with at least 50% of reduction in monthly migraine days (which differ from each patient). Aimovig is proving to show less adverse events associated irrespective of the other factors and showed more effectiveness in reducing the migraine condition and improving the quality of life of the patients.

Published Paper   E-Certificate

MARY MANISHA MANNAM, Dr. Sneha Thakur, & Uma Rani Yadagiri (November-2022). Aimovig serving as a miracle drug for chronic migraine – A clinical Review. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(11), c450-c456. https://ijnrd.org/papers/IJNRD2211257.pdf

Volume 7 Issue 11, November-2022

Pages : c450-c456

Paper Reg. ID: IJNRD_184214

Published Paper Id: IJNRD2211257

Downloads: 000122254

Research Area: Pharmacy

Author Type: Indian Author

Country: RANGA REDDY , TELANGANA, INDIA

Published Paper PDF: https://ijnrd.org/papers/IJNRD2211257.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2211257

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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