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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Review on design synthesis of new Benzimidazole and Benzothiozole fused ring derivatives for anti cancer an anti microbial activity |
| Authors Name: | Junaid Tantray , Akhilesh Patel , Sourabh Kosey , Ramesh Kumar , Mohd Zaid |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_184190
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| Published Paper Id: | IJNRD2211248 |
| Published In: | Volume 7 Issue 11, November-2022 |
| DOI: | |
| Abstract: | Over the course of more than a century, researchers have researched the characteristics of benzimidazole and its derivatives. Substitutes and intermediates for the synthesis of compounds with potential as pharmacological or biological agents include benzimidazole derivatives. Antiulcer, anticancer, and anthelmintic species are just a few of the therapeutic areas where substituted benzimidazole derivatives have found use. This article provides a systematic assessment of recent advancements in benzimidazole-based molecules across the entire spectrum of medicinal chemistry as anticancer agents.In order to assist medicinal chemists in creating an SAR on benzimidazole drugs/compounds, this review will be further helpful for the researcher based on substitution pattern around the nucleus.A bicyclic molecule of the heterocyclic class is benzothiazole (BTA). BTA derivatives have a wide range of biological effects, including those against cancer, inflammation, tumours, viruses, bacteria, proliferative cells, diabetes, convulsions, tuberculosis, leishmaniasis, histamine, and fungi, among others. The metalloenzyme carbonic anhydrase was significantly inhibited by the BTA scaffolds (CA). In this review, a thorough literature assessment over the previous 10 years reveals that BTA derivatives are primarily used as anticancer medicines. These substances work against different cancer cell lines by a variety of methods, some of which have not been well researched or understood. On the other hand, more research has been done on how BTA derivatives might block tumour-associated CAs, and these substances may be used as anticancer leads for the developmentof treatments for tumours that are under-oxygenated |
| Keywords: | Benzimidazole, synthesis, pharmacological activity, antitubercular, anticancer, Benzothiazole; anticancer agent; drug targets; scaffold; carbonic anhydrase inhibitor |
| Cite Article: | "Review on design synthesis of new Benzimidazole and Benzothiozole fused ring derivatives for anti cancer an anti microbial activity", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 11, page no.c373-c388, November-2022, Available :http://www.ijnrd.org/papers/IJNRD2211248.pdf |
| Downloads: | 000118747 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2211248 Registration ID: 184190 Published In: Volume 7 Issue 11, November-2022 DOI (Digital Object Identifier): Page No: c373-c388 Country: Jaipur, Jaipur, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2211248 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2211248 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
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