Design , Synthesis and Biological Evaluation of 1,2,4-triazole as an Antimicrobial agent.

Registration ID: IJNRD_184141

Published ID: IJNRD2211156

DOI: Click Here to Get

Sachi Dixit , Dr. Parulben Mehta , Dr. Shivakant Shukla

1,2,4-Triazole , Hydrazine hydrate , antimicrobial agent , antibacterial activity.

New compounds were synthesized containing 1,2,4-triazole derivatives and tested for their antibacterial activity against gram positive and gram positive strains. A series of N-(3-(4-fluorophenyl)-5-mercaptp-4H-1,2,4-triazole-4-yl)-2-(substituted amines)acetamide were synthesized by esterification of 4- fluorobenzoic acid and further cyclization of hydrazide which is followed by reaction of carbon – di -sulfide and potassium hydrozide with the formation of intermediate potassium salt. The triazole prepared was subjected to N-acetylation with the treatment of choro acetyl chloride and formed the acetamide. The obtained nucleus was subjected to form different substituted derivatives with the treatment of 5 different secondary amines. The compounds were synthesized by conventional method and the stuctures of newly synthesized compounds were characterized by performing various physical as spectral techniques. This involves TLC, M.P , UV spectroscopy , FTIR and NMR spectroscopy . the antibacterial assay was performed for all the synthesized compounds by well diffusion method. The antibacterial screening reveals that the compound N-(3-(4-fluoro[phenyl)-5-mercapto-4H-1,2,4-triazole-4-yl)-2-((4-fluorophenyl)amino)acetamide (SA-03) was showed more promised and significant zone of incubation against Bacillus Subtilis and Pseudomonas aeruginosa ad show moderate activity as that of Standard Ofloxacin and Gentamycin against gram positive ad gram negative bacteria .

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Sachi Dixit, Dr. Parulben Mehta, & Dr. Shivakant Shukla (November-2022). Design , Synthesis and Biological Evaluation of 1,2,4-triazole as an Antimicrobial agent.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(11), b492-b499. https://ijnrd.org/papers/IJNRD2211156.pdf

Volume 7 Issue 11, November-2022

Pages : b492-b499

Paper Reg. ID: IJNRD_184141

Published Paper Id: IJNRD2211156

Downloads: 000121990

Research Area: Pharmacy

Country: Bhopal, Madhya Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2211156.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2211156

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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