FACTORS AFFECTING ON THE SOLUBILITY AND BIOAVAILABILITY OF PHARMACEUTICAL DRUG AND DOSAGE FORM THROUGH SOLUBILITY MECHANISM.

FACTORS AFFECTING ON THE SOLUBILITY AND BIOAVAILABILITY OF PHARMACEUTICAL DRUG AND DOSAGE FORM THROUGH SOLUBILITY MECHANISM.

Registration ID: IJNRD_184149

Published ID: IJNRD2211141

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Alisha S. Shinde , Saurabh S. Machale , Shweta N. Desai , Suraj Warungase , Rajesh Oswal

Solubility, Particle, bioavailability, Absorption

The study on solubility yields information about the structure and intermolecular forces of drugs. Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists. General parameters affecting solubility are particle size, shape and surface area physicochemical properties of drugs, physical forms of drugs, solvents, pH of the medium, temperature and use of surfactants. This article also provides an overview of variables that can affect drug absorption following oral administration in recent years, including both physicochemical properties of the drug and physiological factors of the body. The oral absorption of a drug is a complex process depending upon these factors and their interactions with each other. Solubility and permeability are considered as the major physicochemical factor that affect the rate and extent of oral drug absorption, moreover other physicochemical properties always show their effects to drug absorption via affecting solubility and permeability.

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"FACTORS AFFECTING ON THE SOLUBILITY AND BIOAVAILABILITY OF PHARMACEUTICAL DRUG AND DOSAGE FORM THROUGH SOLUBILITY MECHANISM.", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 11, page no.b354-b364, November-2022, Available :https://ijnrd.org/papers/IJNRD2211141.pdf

Volume 7 Issue 11, November-2022

Pages : b354-b364

Paper Reg. ID: IJNRD_184149

Published Paper Id: IJNRD2211141

Downloads: 000121267

Research Area: Pharmacy

Country: Pune, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2211141.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2211141

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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