Paper Title
FACTORS AFFECTING ON THE SOLUBILITY AND BIOAVAILABILITY OF PHARMACEUTICAL DRUG AND DOSAGE FORM THROUGH SOLUBILITY MECHANISM.
Article Identifiers
Authors
Alisha S. Shinde , Saurabh S. Machale , Shweta N. Desai , Suraj Warungase , Rajesh Oswal
Keywords
Solubility, Particle, bioavailability, Absorption
Abstract
The study on solubility yields information about the structure and intermolecular forces of drugs. Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists. General parameters affecting solubility are particle size, shape and surface area physicochemical properties of drugs, physical forms of drugs, solvents, pH of the medium, temperature and use of surfactants. This article also provides an overview of variables that can affect drug absorption following oral administration in recent years, including both physicochemical properties of the drug and physiological factors of the body. The oral absorption of a drug is a complex process depending upon these factors and their interactions with each other. Solubility and permeability are considered as the major physicochemical factor that affect the rate and extent of oral drug absorption, moreover other physicochemical properties always show their effects to drug absorption via affecting solubility and permeability.
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How To Cite (APA)
Alisha S. Shinde, Saurabh S. Machale, Shweta N. Desai, Suraj Warungase, & Rajesh Oswal (November-2022). FACTORS AFFECTING ON THE SOLUBILITY AND BIOAVAILABILITY OF PHARMACEUTICAL DRUG AND DOSAGE FORM THROUGH SOLUBILITY MECHANISM.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(11), b354-b364. https://ijnrd.org/papers/IJNRD2211141.pdf
Issue
Volume 7 Issue 11, November-2022
Pages : b354-b364
Other Publication Details
Paper Reg. ID: IJNRD_184149
Published Paper Id: IJNRD2211141
Downloads: 000122000
Research Area: Pharmacy
Country: Pune, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2211141.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2211141
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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