Paper Title
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF MEMANTINE AND DONEPEZIL IN MARKETED FORMULATION USING HYDROTROPY PHENOMENA
Article Identifiers
Authors
SHUBHANSHI SAXENA , SARITA KAROLE , KAVITA R LOKSH , ANUP CHKARBORTY , UDIT N. SONI
Keywords
Hydrotropy, Aqueous solubility, amphiphile, micellization, solubilizers, micro emulsion, pharmacokinetic properties
Abstract
"Hydrotropy" has been used to designate the increase in solubility of various substances due to the presence of large amounts of additives. Various hydrotropic agents such as sodium salicylate, sodium benzoate, urea, nicotinamide, sodium citrate and sodium acetate have been used to enhance the aqueous solubility of a large number of drugs. The hydrotropes are a special class of compounds that exhibit distinct solution properties. They may self-associate in aqueous medium, comparable to amphiphile self-association or micellization. They are efficient solubilizers and can influence the formation of micelle and micro emulsion. Using hydrotropic agents is one of the easiest ways of increasing water solubility of poorly soluble drugs, since it only requires mixing the drugs with the hydrotrope in water. The hydrotrope approach does not require chemical modification of hydrophobic drugs, use of organic solvents, or preparation of emulsion systems. Considerable research has focused on attaching drugs to polymers in order to improve pharmacokinetic properties.
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How To Cite (APA)
SHUBHANSHI SAXENA, SARITA KAROLE, KAVITA R LOKSH, ANUP CHKARBORTY, & UDIT N. SONI (November-2022). METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF MEMANTINE AND DONEPEZIL IN MARKETED FORMULATION USING HYDROTROPY PHENOMENA. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(11), b177-b186. https://ijnrd.org/papers/IJNRD2211118.pdf
Issue
Volume 7 Issue 11, November-2022
Pages : b177-b186
Other Publication Details
Paper Reg. ID: IJNRD_183928
Published Paper Id: IJNRD2211118
Downloads: 000121980
Research Area: Pharmacy
Country: Bhopal, Madhyapradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2211118.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2211118
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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