Paper Title
Oral Insulin Delivery by Utilizing Nanotechnology
Article Identifiers
Authors
Hemant Arvind Narule , Shaikh Habiburrahman , Mohammed Sufiyan , Kuldeep Sanjay Wagh , Gajanan Daphal
Keywords
: oral insulin, absorption barrier, nanodrug delivery system, bioavailability
Abstract
Abstract: Diabetes is a chronic metabolic condition defined by a shortage of insulin in the body, resulting in blood glucose regulation failure. Diabetes patients typically require frequent insulin injections to maintain normal blood glucose levels, which can be an unpleasant method of administration. Long-term medication injection places a significant physical and psychological strain on diabetes patients. The creation of oral insulin formulations is currently a hot and difficult topic in the world of medicine and pharmacy in order to increase patients' adaptability to insulin use and lessen the pain caused by injection. Thus, oral insulin administration is a promising and convenient means of relieving patients. However, because insulin is a peptide medication, it is easily destroyed by stomach enzymes. Furthermore, insulin has a high hydrophilicity, a big molecular weight, and a very limited oral bioavailability. To address these issues in clinical practice, oral insulin delivery nano-systems were devised and built using a rational combination of various nanomaterials and nanotechnology. Such oral nano-systems offer the benefits of high flexibility, small size, simple processing, long-lasting pharmacological activity, and drug controlled-release, which can effectively improve insulin oral bioavailability and efficacy. This study highlights the basic principles and recent accomplishments in oral insulin delivery nano-systems, including the physiological absorption barrier of oral insulin and the development of materials to nanostructures for oral insulin delivery nano-systems.
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How To Cite (APA)
Hemant Arvind Narule, Shaikh Habiburrahman, Mohammed Sufiyan, Kuldeep Sanjay Wagh , & Gajanan Daphal (November-2022). Oral Insulin Delivery by Utilizing Nanotechnology. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(11), a606-a621. https://ijnrd.org/papers/IJNRD2211067.pdf
Issue
Volume 7 Issue 11, November-2022
Pages : a606-a621
Other Publication Details
Paper Reg. ID: IJNRD_183906
Published Paper Id: IJNRD2211067
Downloads: 000121975
Research Area: Pharmacy
Country: Chandrapur, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2211067.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2211067
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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