Spectroscopic Method For Quantification Of Escitalopram Oxalate In Bulk And Tablet Dosage Form

Registration ID: IJNRD_183781

Published ID: IJNRD2211063

DOI: Click Here to Get

Y.ANAND KUMAR , Avanish Srivastav , Neeladri Srinivasulu , Aayush Nahar , Syed Hafeez Pasha Qhadri

Keywords: Escitalopram Oxalate, UV spectroscopy, Validation, Accuracy, Precision

Two new simple and accurate solvent mediums have been presented for the quantification of Escitalopram Oxalate (ESC) in tablet dosage form. A linear relationship found in the concentration range of 1-24 µg/ml for two proposed mediums viz., Methanol: DW (1:3) solution and Methanol: 0.1N HCl (1:2) solution. The goodness of fit study suggest good correlation coefficient (R2 - 0.9998 and 0.9998 for proposed methods) shows the validity of Beer’s law with intercept response < 2% calculated by the least square method indicating functional linearity between the concentration of analyte and the absorbance. Based on standard deviation of the response and slope, the LOD values for ESC for the proposed mediums found to be 0.348±0.00238 μg/ml, 0.273±0.0014 μg/ml and LOQ values found to be 1.046±0.002458 μg/ml, 0.823±0.00065 μg/ml with % RSD values less than 2. The proposed methods were successfully applied to the determination of commercially available tablets with a high percentage of recovery, good accuracy and precision.

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Y.ANAND KUMAR, Avanish Srivastav, Neeladri Srinivasulu, Aayush Nahar, & Syed Hafeez Pasha Qhadri (November-2022). Spectroscopic Method For Quantification Of Escitalopram Oxalate In Bulk And Tablet Dosage Form. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(11), a568-a575. https://ijnrd.org/papers/IJNRD2211063.pdf

Volume 7 Issue 11, November-2022

Pages : a568-a575

Paper Reg. ID: IJNRD_183781

Published Paper Id: IJNRD2211063

Downloads: 000121981

Research Area: Pharmacy

Country: RAICHUR, KARNATAKA, INDIA

Published Paper PDF: https://ijnrd.org/papers/IJNRD2211063.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2211063

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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