Paper Title
Evaluation of Hyaluronidase activity of proprietary date seed extract (SesZenNHAâ„¢) for skin health applications
Article Identifiers
Authors
Ms. Sneha Badak , Ms.Ratna Upadhyay , Mr. Mihir Gadani , Ms. Supriya Raut
Keywords
Hyaluronan, hyaluronidase inhibitors, bioactive molecules, date seeds, Indian senna
Abstract
Hyaluronic Acid or Hyaluronan is a glycosaminoglycan that is present in various connective and epithelial tissues. It increases viscosity of the fluid in synovial joints to reduce friction between bones. HA is a major component of the skin. When skin is exposed to UV, hyaluronin is degraded and skin cells reduce production of HA. Hyaluronic acid is degraded by hyaluronidase enzymes. Various biological sources are being explored to source hyaluronidase inhibitors. Polyphenols such as alkaloids, flavonoids and terpenes have demonstrated inhibition against HAases. In this study we have evaluated the HAase inhibition activity of date seed extract (SesZenNHA™) against the well established plant based HA inhibitor which comes from Senna seeds . The polysaccharide content, which is believed to be the phytochemical responsible for HA inhibitory activity of Date seeds, was found to be 18.73% glucose equivalents as against Seena Polysaccharides of 7%. In hyaluronidase inhibition activity,IC20 of date-seed extract was estimated to be 0.5mg/ml whereas IC20 of senna seed extracts was 2 mg/ml. Hence the proprietary ingredient derived from date seed holds 4 times better potential for HA inhibition.
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How To Cite (APA)
Ms. Sneha Badak, Ms.Ratna Upadhyay, Mr. Mihir Gadani, & Ms. Supriya Raut (October-2022). Evaluation of Hyaluronidase activity of proprietary date seed extract (SesZenNHAâ„¢) for skin health applications. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(10), 446-451. https://ijnrd.org/papers/IJNRD2210053.pdf
Issue
Volume 7 Issue 10, October-2022
Pages : 446-451
Other Publication Details
Paper Reg. ID: IJNRD_183339
Published Paper Id: IJNRD2210053
Downloads: 000121981
Research Area: Engineering
Country: Mumbai, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2210053.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2210053
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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