FORMULATION AND EVALUATION OF EXTENDED RELEASE ALFUZOSIN HYDROCHLORIDE TABLETS

Registration ID: IJNRD_183394

Published ID: IJNRD2210045

DOI: Click Here to Get

S.Mounika

extended release, matrix drug delivery, excipients, preformulation studies, alfuzosin HCl.

Preformulation studies indicated that the drug had passable flow property and good compressibility. From the drug-excipient interaction study it was observed that there was no significant physical change in the drug when mixed with excipients and kept under stressed conditions for one month. Absence of interaction between the drug and the excipients was confirmed by FTIR graph of pure drug and with various excipients. Based on the innovator’s product the target in vitro release profile was set to 10-20% at 1 hr, 20-30% at 2 hr, 40-55% at 6 hr, 60-80% at 12 hr, 80-90% at 18 hr, and NLT 85% at 20 hr. The matrix tablets were formulated by wet granulation technique using hydrophilic, hydrophobic and waxy polymers in various combinations. Initial trials indicated that the combination of EC & HPMC K100M based granules were not helpful in successfully retarding the release. Further addition of HCO both intra granularly and extra granularly helped in retarding the drug release. However, a combination of all these polymers was required to obtain the target release profile. The granules were evaluated for bulk density, tapped density, carr’s index, hausner’s ratio and angle of repose. The prepared tablets were evaluated for thickness, hardness, percentage friability and drug content. All the results obtained were found to be satisfactory. The final formulation having 5.8% HCO, 2.1% EC and 34.2% HPMC K100M was found to be successful in prolonging the drug release over a period of 20 hrs. The drug release was found to be by anomalous diffusion. The prepared tablets were found to be stable at accelerated stability conditions. The prepared matrix tablets of Alfuzosin HCl would be thus helpful in reducing the dosing frequency. The method is also adoptable for large scale production.

Published Paper   E-Certificate

S.Mounika (October-2022). FORMULATION AND EVALUATION OF EXTENDED RELEASE ALFUZOSIN HYDROCHLORIDE TABLETS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(10), 378-391. https://ijnrd.org/papers/IJNRD2210045.pdf

Volume 7 Issue 10, October-2022

Pages : 378-391

Paper Reg. ID: IJNRD_183394

Published Paper Id: IJNRD2210045

Downloads: 000121986

Research Area: Pharmacy

Country: Secunderabad,, telangana, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2210045.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2210045

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 10 | October 2025

IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.

The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.

Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.

How to submit the paper?

By Our website

Click Here to Submit Paper Online

By Mail

Send your paper to editor@ijnrd.org

Important Dates for Current issue

Paper Submission Open For: October 2025

Current Issue: Volume 10 | Issue 10 | October 2025

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-Oct-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.

Subject Category: Research Area

Call for Paper: More Details