FORMULATION AND EVALUATION OF TENOXICAM BUCCAL PATCHES FOR ARTHRITIC PAIN

FORMULATION AND EVALUATION OF TENOXICAM BUCCAL PATCHES FOR ARTHRITIC PAIN

Registration ID: IJNRD_183372

Published ID: IJNRD2210035

DOI: Click Here to Get

Dr. Wajid Chaus. , Atiya shaikh , Rajesh Raut , Sneha Khandale , Priya Deshmukh

Tenoxicam, Gelatin, sodium alginate, Chitosan, gum patches, Mucoadhesive drug delivery.

The main objective of the present study was to improve the bioavailability of Tenoxicam and decrease the frequency of dosage form administration by mucoadhesive drug delivery system. Tenoxicam is an NSAIDS belonging to the class non selective cox-2 inhibitor, well known to cause gastrointestinal disorders and renal effects when given orally. A buccal patch for systemic administration of Tenoxicam in oral cavity were developed using polymers chitosan, sodium alginate, Gelatin, in order to deliver the drug to the particular region of the body for extended period of time, maximizing the drug availability, minimize the adverse effects, avoiding the first pass metabolism and thereby improving patient compliance. The formulated patches were evaluated for Mass uniformity and thickness uniformity, folding endurance, Drug content uniformity, Measurement of surface pH, Swelling index, Tensile strength, bioadhesion test, In vitro residence time, In vitro membrane permeation studies. Drug polymer compatibility studies were carried out by FTIR. & shows drug is compatible with polymers. The in vitro drug releases and in-vitro drug permeation studies showed that drug was released from the patches and permeated through the porcine buccal mucosa and hence the formulated buccal patches possibly permeate through the human buccal membrane also.

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"FORMULATION AND EVALUATION OF TENOXICAM BUCCAL PATCHES FOR ARTHRITIC PAIN", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 10, page no.287-295, October-2022, Available :https://ijnrd.org/papers/IJNRD2210035.pdf

Volume 7 Issue 10, October-2022

Pages : 287-295

Paper Reg. ID: IJNRD_183372

Published Paper Id: IJNRD2210035

Downloads: 000121143

Research Area: Pharmacy

Country: Latur, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2210035.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2210035

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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