Paper Title
DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS AN ANTIMICROBIAL AGENTS
Article Identifiers
: Keywords
Docking, 3-Acetyl coumarin, Pyrazoline, hydrazine hydrate, Antibacterial activity
Abstract
New compounds were designed based on docking studies. GLIDE (Grid-based ligand docking with energetics, version autodock vina 1.5.7) was used to dock all the designed pyrazole containing coumarin derivatives within the binding site (PDB ID 4cv0). Docking based synthesis of coumarin contain pyrazoline derivatives, being used as potential medicinal agents, 3-Acetyl-2H-chromen-2one (I) was prepared by Knoevenagel condensation of salicylaldehyde with ethyl acetoacetate in presence of piperidine. A series of 3-[(2E)-3-substituted-prop-2-enoyl]-2H-chromen-2-one derivatives (II A-H) were prepared by Claisen-Schmidt condensation of 3-acetyl coumarin with aromatic aldehydes. Treatment of 3-substituted cinnamoyl coumarin with hydrazine hydrate in the presence of ethanol gave [5-substitutedphenyl]-4, 5-dihydro-1H pyrazol-3-yl]-2H-chromen-2-one (III A-H). Title compound were synthesized by conventional method. The structures of the newly synthesized compounds were confirmed by FT-IR and 1H-NMR spectroscopy. All the synthesized compounds were tested for their antibacterial activities using filter paper disc method. The antibacterial activity screening revels that the compound 3A, 3B and 3C are promising against S. aureus and E.coli. show moderate activity as that of standard amikacin against gram positive and gram-negative bacteria.
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How To Cite (APA)
Mr. Mukesh Pawar, Dr. Govind Nayak, Dr. Parul Mehta, & Dr. Shivakant Shukla (September 2022). DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS AN ANTIMICROBIAL AGENTS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(9), 1590-1598. https://ijnrd.org/papers/IJNRD2209189.pdf
Issue
Volume 7 Issue 9, September-2022
Pages : 1590-1598
Other Publication Details
Paper Reg. ID: IJNRD_183239
Published Paper Id: IJNRD2209189
Downloads: 000122256
Research Area: Pharmacy
Author Type: Indian Author
Country: Bhopal, Bhopal, Madhya Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2209189.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2209189
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