DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS AN ANTIMICROBIAL AGENTS

DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS AN ANTIMICROBIAL AGENTS

Registration ID: IJNRD_183239

Published ID: IJNRD2209189

DOI: Click Here to Get

Mr. Mukesh Pawar , Dr. Govind Nayak , Dr. Parul Mehta , Dr. Shivakant Shukla

Docking, 3-Acetyl coumarin, Pyrazoline, hydrazine hydrate, Antibacterial activity

New compounds were designed based on docking studies. GLIDE (Grid-based ligand docking with energetics, version autodock vina 1.5.7) was used to dock all the designed pyrazole containing coumarin derivatives within the binding site (PDB ID 4cv0). Docking based synthesis of coumarin contain pyrazoline derivatives, being used as potential medicinal agents, 3-Acetyl-2H-chromen-2one (I) was prepared by Knoevenagel condensation of salicylaldehyde with ethyl acetoacetate in presence of piperidine. A series of 3-[(2E)-3-substituted-prop-2-enoyl]-2H-chromen-2-one derivatives (II A-H) were prepared by Claisen-Schmidt condensation of 3-acetyl coumarin with aromatic aldehydes. Treatment of 3-substituted cinnamoyl coumarin with hydrazine hydrate in the presence of ethanol gave [5-substitutedphenyl]-4, 5-dihydro-1H pyrazol-3-yl]-2H-chromen-2-one (III A-H). Title compound were synthesized by conventional method. The structures of the newly synthesized compounds were confirmed by FT-IR and 1H-NMR spectroscopy. All the synthesized compounds were tested for their antibacterial activities using filter paper disc method. The antibacterial activity screening revels that the compound 3A, 3B and 3C are promising against S. aureus and E.coli. show moderate activity as that of standard amikacin against gram positive and gram-negative bacteria.

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"DESIGN SYNTHESIS AND BIOLOGICAL EVALUATION OF COUMARIN DERIVATIVES AS AN ANTIMICROBIAL AGENTS", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 9, page no.1590-1598, September 2022, Available :https://ijnrd.org/papers/IJNRD2209189.pdf

Volume 7 Issue 9, September-2022

Pages : 1590-1598

Paper Reg. ID: IJNRD_183239

Published Paper Id: IJNRD2209189

Downloads: 000121138

Research Area: Pharmacy

Country: Bhopal, Bhopal, Madhya Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2209189.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2209189

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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