Novel high performance liquid chromatographic method development and validation for the estimation of lasmiditan in marketed formulation

Novel high performance liquid chromatographic method development and validation for the estimation of lasmiditan in marketed formulation

Registration ID: IJNRD_183171

Published ID: IJNRD2209178

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Pragati Puriya , Lavakesh Kumar Omray , Pushpendra soni

UV, RP-HPLC, Lasmiditan, Linearity, Accuracy

UV and RP-HPLC method was developed for estimation of Lasmiditan in bulk and tablets dosage form by isocratically using Methanol: Acetonitrile in the ratio of 50:50 v/v as mobile phase, Thermo C-18 column (4.6 x 250mm, 5μparticle size) column as stationary phase and chromatogram was recorded at 228 nm. Then developed method was validated by using various parameters. The linearity of analytical method to elicit test results that are proportional to the concentration of analyte in sample within a given range. Specificity of the method was determined and the peaks of diluent, mobile phase and excipient of tablets did not interfere with standard peaks Lasmiditan. The validity and reliability of proposed methods were assessed by recovery studies. The recovery of added standards (80%, 100% and 120%) was found at three replicate and three concentrations level. The value of % means just close to 100, SD and % RSD are less than 2 indicate the accuracy of method. The assay value of drugs was close to 100, SD and % RSD are less then 2 indicate the no interference of excipient in the estimation of drug

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"Novel high performance liquid chromatographic method development and validation for the estimation of lasmiditan in marketed formulation", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 9, page no.1509-1519, September-2022, Available :https://ijnrd.org/papers/IJNRD2209178.pdf

Volume 7 Issue 9, September-2022

Pages : 1509-1519

Paper Reg. ID: IJNRD_183171

Published Paper Id: IJNRD2209178

Downloads: 000121189

Research Area: Engineering

Country: -, --, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2209178.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2209178

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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