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IJNRD
INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

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Impact Factor : 8.76

Issue per Year : 12

Volume Published : 7

Issue Published : 78

Article Submitted : 4554

Article Published : 2130

Total Authors : 5208

Total Reviewer : 660

Total Countries : 73

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Paper Title: “Design and in-vitro evaluation of lovastatin loaded translabial strips.”
Authors Name: Mr. Sukumar Maruti Lande , Mr. Prashant Shankar Misal , Mr. Hemant Balu Bansode
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IJNRD_182963
Published Paper Id: IJNRD2209094
Published In: Volume 7 Issue 9, September-2022
DOI:
Abstract: There has been an increased interest and challenge in the delivery of an active ingredients through the skin. It is a viable administration route for potent, low molecular weight therapeutic agents susceptible to first pass metabolism. Translabial delivery promises many advantages which include non-invasiveness, prolonged drug level in the blood stream, reduced side effect, improved bioavailability, better patient compliance and easy termination of drug administration. Lovastatin is a Lipid lowering agents drug widely used in treatment of CVS disease. Oral therapy of drug is effective, but the clinical use is often limited because of its serious gastrointestinal side effect such as irritation of the gastrointestinal mucosa. The objective of present study was to investigate the suitability of HPMC and Na-CMC films as a vehicle for translabial delivery of Lovastatin. Films were prepared with different drug polymer ratio by solvent casting technique. The films were evaluated for their physico-chemical characteristics like, thickness, weight, drug content, folding endurance and drug polymer interaction. Preformulation studies such as identification, solubility, melting point, and partition coefficient were carried out. The thickness of films was in the range of 0.194 to 0.362 mm. In vitro release was carried out by using Franz diffusion cell in PBS 6.8. FT-IR and DSC studies showed the absence of drug polymer interactions. The cumulative percent release of drug was inversely proportional to polymer concentration.
Keywords: Translabial film; Lovastatin ; Physicochemical; In-vitro release; Solvent casting.
Cite Article: "“Design and in-vitro evaluation of lovastatin loaded translabial strips.”", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.7, Issue 9, page no.803-817, September-2022, Available :http://www.ijnrd.org/papers/IJNRD2209094.pdf
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ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publication Details: Published Paper ID:IJNRD2209094
Registration ID: 182963
Published In: Volume 7 Issue 9, September-2022
DOI (Digital Object Identifier):
Page No: 803-817
Country: Pandharpur, Maharashtra, India
Research Area: Pharmacy
Publisher : IJ Publication
Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2209094
Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2209094
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016

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