OPTIMIZATION OF THERMOREVERSIBLE NASAL GEL OF CARBAMAZEPINE FOR BETTER CONTROL IN CHRONIC EPILEPSY

OPTIMIZATION OF THERMOREVERSIBLE NASAL GEL OF CARBAMAZEPINE FOR BETTER CONTROL IN CHRONIC EPILEPSY

Registration ID: IJNRD_182758

Published ID: IJNRD2209015

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Utkarsha S. Shivsharan , Avinash H. Hosmani , Yogesh S. Thorat

Thermoreversible gel, Stimulisensitive, HPMC, Pluronic, Carbamazepine, Epilepsy

The aim of present work was to formulate thermosensitive in situ gel of carbamazepine (CBZ), an anti-epileptic agent. In situ nasal gel of CBZ was formulated by cold method using Pluronic F68 and Pluronic F127 as thermoreversible stimuli sensitive polymer along with two different grades of hydroxypropyl methyl cellulose as mucoadhesive polymer. It is thought that the thermo-reversion and mucoadhesion would synergistically enhance the residence time of the drug in the nasal cavity and also impart better penetration of the drug to brain for the site-specific activity. The sustained release obtained from the viscous gel makes the treatment even better especially in the chronic epileptic conditions like tonic-clonic seizures. The prepared formulations were evaluated for pH, clarity, in vitro gelation, gelling strength, mucoadhesion, in vitro drug release and accelerated stability studies. Results have shown that final batches of in situ gels were having desired gelation temperature to provide pourable ‘Sol’ form at room temperature and ‘Gel’ form in the nasal cavity with a good gel strength and mucoadhesion required for nasal retention. Formulations showed polymer concentration dependent drug release retardation over a period of 6 hrs.

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"OPTIMIZATION OF THERMOREVERSIBLE NASAL GEL OF CARBAMAZEPINE FOR BETTER CONTROL IN CHRONIC EPILEPSY", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.7, Issue 9, page no.142-146, September-2022, Available :https://ijnrd.org/papers/IJNRD2209015.pdf

Volume 7 Issue 9, September-2022

Pages : 142-146

Paper Reg. ID: IJNRD_182758

Published Paper Id: IJNRD2209015

Downloads: 000121141

Research Area: Pharmacy

Country: Solapur, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2209015.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2209015

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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