Paper Title
HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES 0F AGANOSMA CYMOS LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC MICE
Article Identifiers
Authors
Vishal Satish Patil , Ankita Bankhele , Rajesh J oswal
Keywords
KEYWORDS: Diabetes, Antidiabetic, Aganosma cymos, Lipid Profile.
Abstract
ABSTRACT Diabetes mellitus (DM) is a systemic metabolic disorders with several major health complications affecting both the quality and the length of life. The purpose of this study is to appraise the antidiabetic and antihyperlipidemic activities of the Aganosma cymos leaves. Diabetes was induced in overnight fasted mice by a single intraperitoneal injection of Streptozotocin (60 mg/kg body weight) in a 0.1 M sodium citrate buffer (pH 4.5). The animals were divided into five groups with five animals in each and treated with methanolic extract of aganosma cymos leaves at dose 100 mg/kg and 200 mg/kg body weight respectively. The results showed that aganosma cymos leaves decrease blood glucose level significantly (p<0.001 to p<0.01) and also regulated parameters of lipid profile levels (TG, TC, LDL, VLDL, and HDL) significantly (p<0.001 to p<0.01) in experimental model of diabetes mellitus.levels of serum SGPT, SGOT and CRP were also adjusted to the normal level notably (p<0.001 to p<0.01) by the oral administration of methanolic extract of AGANOSMA CYMOS leaves (MACL). The results obtained from this study indicate that the methanolic extract of Aganosma cymos leaves contains bioactive substances with hypoglycemic potency.
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How To Cite (APA)
Vishal Satish Patil, Ankita Bankhele, & Rajesh J oswal (August-2022). HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES 0F AGANOSMA CYMOS LEAVES IN STREPTOZOTOCIN INDUCED DIABETIC MICE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(8), 1121-1129. https://ijnrd.org/papers/IJNRD2208122.pdf
Issue
Volume 7 Issue 8, August-2022
Pages : 1121-1129
Other Publication Details
Paper Reg. ID: IJNRD_182583
Published Paper Id: IJNRD2208122
Downloads: 000121984
Research Area: Pharmacy
Country: Pune, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2208122.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2208122
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition


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