Protective effect of sodium thiosulfate (hydrogen sulfide donor) against the pathological alterations in thyroid and testicular glands induced by ionizing gamma- radiation and/or cyclophosphamide in male rats.

Registration ID: IJNRD_182465

Published ID: IJNRD2208093

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Ashraf kassem , Eman FS Taha , Azza Hassan , Ahmed H. Osman

Cyclophosphamide, Sodium thiosulphate, ionizing gamma radiation, histopathology, thyroid and testis

Background: Radiation therapy (RT) alone or in combination with chemotherapy, surgery or both is a major treatment option for solid malignancies. Sodium thiosulfate (STS), a donor of H2S, is a water-soluble inorganic sodium slat that has antioxidant and anti-inflammatory properties. Methods: Rats of all groups received STS for 14 days before treatment with cyclophosphamide and/or ionizing gamma radiation. The normal control rats received saline only. The other groups were then treated with cyclophosphamide (50mg/kg/wk. for 3 wk.) or exposed to gamma radiation (3 Gy/wk. for 3 weeks up to a total cumulative dose of 9 Gy). Then all groups received STS three times per week for 3 successive weeks during CYP and/or exposure to gamma- radiation. Results: STS reduced malondialdehyde (MDA) and elevated superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and reduced glutathione (GSH). Additionally, STS elevated the reduced gonadotropin, follicle-stimulating hormone (FSH) and the male sex hormone, testosterone. STS elevated thyroid hormones, triiodothyronine (T3) and thyroxine (T4). Furthermore, STS reduced the pathological deteriorations of testicular seminiferous tubules and thyroid follicles which reflect on caspase-3 and TNF-α histological markers. Conclusion: This study reveals that STS exerted protective effect confirmed by attenuation of oxidative stress and apoptosis and amelioration of the histopathological changes of both thyroid and testicular glands.

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Ashraf kassem, Eman FS Taha, Azza Hassan, & Ahmed H. Osman (August-2022). Protective effect of sodium thiosulfate (hydrogen sulfide donor) against the pathological alterations in thyroid and testicular glands induced by ionizing gamma- radiation and/or cyclophosphamide in male rats.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(8), 871-885. https://ijnrd.org/papers/IJNRD2208093.pdf

Volume 7 Issue 8, August-2022

Pages : 871-885

Paper Reg. ID: IJNRD_182465

Published Paper Id: IJNRD2208093

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Research Area: Pathology

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