Paper Title

Analytical Method Development and Validation for Simultaneous estimation of Metformin Hydrochloride and Empagliflozin by RP-HPLC in Bulk and it’s Tablet dosage form

Article Identifiers

Registration ID: IJNRD_182378

Published ID: IJNRD2208039

DOI: Click Here to Get

Authors

Nutan Rajendra Chapaitkar , Dr. D.V. Derle

Keywords

Metformin Hydrochloride Empagliflozin, Method Development, Validation, HPLC, Linearity, LOD, LOQ, Precision.

Abstract

Metformin is a class of drug called Biguanides. It is used to control high blood sugar in type 2 diabetes ,hence it help to prevent kidney damage, blindness, nerve damage, sexual problems, while in case of Empagliflozin it is belong to class sodium glucose co- transporter SGLT-2 inhibitor it lowers blood sugar by causing kidney to get rid of more glucose in the urine. The present work is based on excludation of buffer solution in mobile phase and use of cheap solvent in development of cost effective method. Result: The Chromatographic separation was achieved on Chemsil C18 column used as stationary phase and Methanol : Water (65:35% v/v) used as mobile phase. The flow rate was 1ml/min and the absorbance was monitored at 227nm. Metformin Hydrochloride and Empagliflozin was eluted at 2.273min and 4.117min. The procedure and capabilities were evaluated against system suitability, linearity, precision ,accuracy, LOD,LOQ and Robustness as per ICH Q2 (R1) guidelines. The method shows good linearity ( R2=0.9992 and 0.9996)

How To Cite (APA)

Nutan Rajendra Chapaitkar & Dr. D.V. Derle (August-2022). Analytical Method Development and Validation for Simultaneous estimation of Metformin Hydrochloride and Empagliflozin by RP-HPLC in Bulk and it’s Tablet dosage form. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(8), 340-355. https://ijnrd.org/papers/IJNRD2208039.pdf

Issue

Volume 7 Issue 8, August-2022

Pages : 340-355

Other Publication Details

Paper Reg. ID: IJNRD_182378

Published Paper Id: IJNRD2208039

Downloads: 000121999

Research Area: Pharmacy

Country: Aurangabad, Maharastra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2208039.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2208039

About Publisher

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG

Publication Timeline

Peer Review
Through Scholar9.com Platform

Article Preview: View Full Paper

Call For Paper

Call For Paper - Volume 10 | Issue 10 | October 2025

IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.

The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.

Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.

How to submit the paper?

Important Dates for Current issue

Paper Submission Open For: October 2025

Current Issue: Volume 10 | Issue 10 | October 2025

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-Oct-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.

Subject Category: Research Area

Call for Paper: More Details