Paper Title
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF FLUCONAZOLE AND IVERMECTIN TABLET DOSAGE FORM.
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Keywords
Fluconazole, Ivermectin, Simultaneous equation, UV Spectrophotometer, Validation.
Abstract
The simple, accurate, and precise UV spectrophotometric method has developed for simultaneous estimation of Fluconazole and Ivermectin in bulk tablet formulation. Two wavelength 273 nm and 253 nm were selected for estimation of Fluconazole and Ivermectin by simultaneous equation method respectively. UV spectrophotometric method was developed as per ICH guideline using O-phosphoric acid and water Mobile phase. Fluconazole and Ivermectin individually follows the Beer-Lamberts Law over concentration range 120-180 and 4.8-7.2μg/mL, regression of coefficient was found to be r2=0.9966 and r2=0.9954 respectively. The percentage recovery was found to be 98 to 101 % at three different levels. The proposed method was successfully applied for determination of Fluconazole and Ivermectin in tablet dosage form as per ICH guideline the result of the analysis were validated statistically and were found to be satisfactory.
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How To Cite (APA)
Vishal Uttreshwar Thodsare, Kale S. Sagar, Dr. Shinde G Monika, Thombare B Vaibhav, & Mane T Swati (August-2022). ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF FLUCONAZOLE AND IVERMECTIN TABLET DOSAGE FORM.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 7(8), 86-95. https://ijnrd.org/papers/IJNRD2208011.pdf
Issue
Volume 7 Issue 8, August-2022
Pages : 86-95
Other Publication Details
Paper Reg. ID: IJNRD_182312
Published Paper Id: IJNRD2208011
Downloads: 000122033
Research Area: Pharmacy
Author Type: Indian Author
Country: Solapur, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2208011.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2208011
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